华中师范大学学报（自然科学版）2018，Vol.52Issue(3)：341-346,6.DOI:10.19603/j.cnki.1000-1190.2018.03.009
新型含联苯基的多氟代吡唑衍生物的合成及Aurora激酶A抑制活性测试
Synthesis and inhibition activity assay for Aurora kinase A of novel multi-fluorin pyrazol derivatives with biphenyl
摘要
Abstract
Due to the structure diversity and biological activities variety of pyrazole derivatives,so that they are a kind of important compounds in drug research.Novel multi fluorin pyrazol derivatives with bipheny (4a ～ 4tf) were synthesized via F-Cacylation,condensation,cyclization reaction starting from 2,4-difluorin-bipheny.The structure of the target compounds (4a ～ 4f) were confirmed by IR,1H NMR,13C NMR and HRMS-ESI spectra.The inhibition activity for Aurora kinase A of the target compounds were tested.Preliminary test results showed that the inhibitory activity for Aurora kinase A was feebleness.关键词
2,4二氟联苯/合成/吡唑衍生物/生物活性Key words
2, 4-difluorin-bipheny/synthesis/pyrazol derivatives/biological activity分类
化学化工引用本文复制引用
陈勇,武文昌,夏雨..新型含联苯基的多氟代吡唑衍生物的合成及Aurora激酶A抑制活性测试[J].华中师范大学学报（自然科学版）,2018,52(3):341-346,6.基金项目
河南省高等学校重点科研项目(192109316007) （192109316007）
河南省新型光电功能材料重点实验室资助项目. （）
