华中师范大学学报（自然科学版）2018，Vol.52Issue(3)：360-365,6.DOI:10.19603/j.cnki.1000-1190.2018.03.012
多重响应性羧甲基壳聚糖智能水凝胶的制备与其响应性研究
Preparation of multi-response carboxymethyl chitosan intelligent hydrogels and their response studies
摘要
Abstract
The cross-linking of intelligent hydrogels and their responsiveness have an im portant effect on the activity of drugs (especially polypeptide or protein drugs) and controlled release.In this paper,mercapto-carboxymethyl chitosan was used to prepare the multi-responsive intelligent hydrogels.The swelling behavior of the hydrogels,the degradation behavior by the colonic enzyme and the reduction behavior by glutathione were studied.The hydrogels showed pH sensitivity,enzyme sensitivity and reduced susceptibility.The thiol content of thiolated carboxymethyl chitosan and the degree of crosslinking of hydogel not only affect the swelling behavior of the hydrogels,but also affect their enzymatic degradation.The reducing sensitivity of the hydrogels depends on their degree of disulfide cross-linking.The hydrogels show the potential for the delivery of polypeptides or protein drugs to colon system.关键词
羧甲基壳聚糖/多重响应性/二硫键交联/智能水凝胶Key words
carboxymethyl chitosan/multi response/disulfied bond cross-linking/intelligent hydrogels分类
化学化工引用本文复制引用
向睿,张晓娜,殷鸽,柳家明,雷佳清,何乐童,易英,殷以华..多重响应性羧甲基壳聚糖智能水凝胶的制备与其响应性研究[J].华中师范大学学报（自然科学版）,2018,52(3):360-365,6.基金项目
国家自然科学基金项目(51373130) （51373130）
武汉理工大学国家大学生创新训练计划项目(20171049720004) （20171049720004）
武汉理工大学本科生创新研究基金项目(2016-HS-B1-12). （2016-HS-B1-12）
