华中师范大学学报（自然科学版）2018，Vol.52Issue(3)：366-372,7.DOI:10.19603/j.cnki.1000-1190.2018.03.013
武汉地区丙型肝炎病毒包膜蛋白E1的生物信息学研究
Bioinformatic study of hepatitis C virus envelope protein E1 in Wuhan
摘要
Abstract
The envelope proteins E1 of different HCV genotypes and subtypes in Wuhan were analyzed bioinformatically to predict their secondary structure,nucleotide variability,glycosylation site,hydrophilicity,transmembrane domain,signal peptide,protein modification site,and B cell antigen.The results indicated that envelope proteins E1 of HCVs possess little secondary structure difference;the beginning segment of the se quence is different from the end segment by several amino acid residues,with hypervariable site in the sequence;the genotype 2a shows the highest consistency;the sequence shows significant glycosylation with multiple glycosylation sites;hydrophilicity areas distribute in the sequence and the genotype 1b shows high score;most subtypes of genotypes 1b,6a,3b,3a have one transmembrane domain,while 2a have two;genotypes 1b,6a,3b,3a have no signal peptide,while 2a has;multiple different modification sites and B cell antigens in the protein sequence,which varies with the genotypes and sub types,exhibiting significant heterogeneity.The study has provided references for demonstrating mechanism of HCV infection and development of region-specific vaccines.关键词
丙型肝炎/生物信息学/武汉/包膜蛋白E1Key words
hepatitis C virus/bioinformatic/Wuhan/envelope protein E1分类
生物科学引用本文复制引用
周小东,万莉,蔡国才,雷行华..武汉地区丙型肝炎病毒包膜蛋白E1的生物信息学研究[J].华中师范大学学报（自然科学版）,2018,52(3):366-372,7.基金项目
四川省卫生厅资助项目(120499). （120499）
