临床口腔医学杂志2018，Vol.34Issue(6)：338-340,3.DOI:10.3969/j.issn.1003-1634.2018.06.006
己糖激酶1及NLRP3信号通路内关键分子在难治性根尖周炎中的表达研究
Expression of hexokinase 1 and key molecules of NLRP3 signaling pathway in refractory apical periodontitis
摘要
Abstract
Objective:To detect the expression of hexokinase 1(HK1) and key molecules of NLRP3 signaling path-way in refractory apical periodontitis. Methods:Twenty patients with refractory apical periodontitis who underwent apical sur-gery were selected to collect the granulation tissue scraped during the operation. And twenty normal periapical tissues were collected from the ambulatory impacted teeth. The expressions of HK1, NLRP3, Caspase-1, IL-1β and IL-18 in the two groups were detected by qRT-PCR. Results:qRT-PCR showed that the mRNA levels of HK1,NLRP3 and Caspase-1 in re-fractory apical periodontitis were significantly higher than those in normal group,while there was no significant differences in mRNA levels of IL-1βand IL-18 between the two groups. Conclusion:HK1/NLRP3/Caspase-1 may play an important role in refractory apical periodontitis,but there may be multiple signaling pathways co-regulate IL-1βand IL-18,and play an im-mune defense effect in refractory apical periodontitis.关键词
难治性根尖周炎/己糖激酶1/NLRP3Key words
Refractory apical periodontitis/Hexokinase 1/NLRP3分类
医药卫生引用本文复制引用
钱雅洁,高雅凡,黎景景,杨卫东..己糖激酶1及NLRP3信号通路内关键分子在难治性根尖周炎中的表达研究[J].临床口腔医学杂志,2018,34(6):338-340,3.基金项目
省重点研发计划(社会发展)项目(BE2016623) （社会发展）
南京市科委—医疗专项(201605043) （201605043）
江苏省第十四批"六大人才高峰"项目 （）
