临床口腔医学杂志2018，Vol.34Issue(6)：358-362,5.DOI:10.3969/j.issn.1003-1634.2018.06.012
糜烂型口腔扁平苔藓三种治疗方法的随机对照研究
Randomized,positive-controlled trial of three methods for erosive oral lichen planus:pilot study
摘要
Abstract
Objective:To investigate the efficacy and safety of traditional Chinese medicine used in the treatment of erosive oral lichen planus( EOLP) by randomized,positive-controlled trial. Methods:The volunteerswere assigned randomly to three groups which received Chinese medicine,western medicine,or combination of Chinese and western medicine respective-ly. The advantages and disadvantages of the three methods were assessed by comparing the score of oral lesions and pain,pa-tients'weight,and adverse effects before and after the treatment. The safety was evaluated by the adverse events that appeared including symptoms,physical and biochemical examination. Results:Totally,90 volunteers were enrolled in this study with 83 completing the trial. No significant difference was found among the three groups in the demographic characters and sexual baseline. The reduced oral lesions score below the baseline in the three groups( Chinese medicine,western medicine,or com-bination of Chinese and western medicine)was 1. 27,2. 21 and 2. 17 repectively,and the decrease was statistically larger in the latter two groups than in the Chinese medicine group. No significant difference was found among the three groups in the reduced pain score. The number of adverse events was reported in three groups was 7,29 and 11 respectively. The total effica-cy rates of three groups was 73. 1%,82. 1% and 89. 7% respectively,with no significant difference found. Conclusion:The treatment of Chinese integrative medicine is a preferred method for erosive oral lichen planus which boasts of both better effi-cacy and relatively good safety.关键词
口腔扁平苔藓/中西医结合/临床试验Key words
Oral lichen planus/Chinese integrative medicine/Clinical trials分类
医药卫生引用本文复制引用
周永梅,戚清权,刘伟,周曾同,沈雪敏..糜烂型口腔扁平苔藓三种治疗方法的随机对照研究[J].临床口腔医学杂志,2018,34(6):358-362,5.基金项目
上海市科学技术委员会医学引导项目(13401905700) （13401905700）
上海交通大学医学院附属第九人民医院临床研究助推计划(JYLJ008) （JYLJ008）
上海市中医药新兴交叉学科资助计划建设项目([2017]10) （[2017]10）
