临床神经外科杂志2018，Vol.15Issue(3)：161-164,4.DOI:10.3969/j.issn.1672-7770.2018.03.001
癫痫外科术后丙戊酸诱发高血氨脑病临床分析
Clinical analysis of valproate-induced hyperammonemic encephalopathy after epilepsy surgery
摘要
Abstract
Objective To explore the clinical features and the experience of diagnosis and treatment of the patients with valproate-induced hyperammonemic encephalopathy ( VHE ) after epilepsy surgery .Methods The clinical symptoms , blood ammonia and its relationship with prognosis of 6 patients with valproate-induced hyperammonemic encephalopathy ( VHE ) underwent epilepsy surgery from February 2012 to December 2017 were analyzed retrospectively , and the diagnosis and treatments experiences were summarized .Results There were 6 patients with VHE , including 2 men and 4 women.All of them presented clinical symptoms with progressive unconsciousness and high blood ammonia 3 to 7 days after surgery .After VHE was diagnosed , valproic acid must be immediately stopped and medicines should be administrated to reduce blood ammonia.All patients recovered consciousness and normal blood ammonia in 8 days.Conclusions VHE is a rare complication , which can lead to serious consequences .Early identification and diagnosis were very important .The patients had good prognosis after valproate withdrawal and symptomatic treatment timely .关键词
癫痫/丙戊酸脑病/高血氨Key words
epilepsy/hyperammonemic encephalopathy/high blood ammonia分类
医药卫生引用本文复制引用
钱会,杨帆,梁爽爽,于晓曼,梁树立,张绍辉..癫痫外科术后丙戊酸诱发高血氨脑病临床分析[J].临床神经外科杂志,2018,15(3):161-164,4.基金项目
国家自然科学基金(81771388) （81771388）
UCB IIS(Investigator initiated Study)资助项目(2095401) （Investigator initiated Study）
