临床神经外科杂志2018，Vol.15Issue(3)：190-192,3.DOI:10.3969/j.issn.1672-7770.2018.03.008
颅内巨大转移瘤分次立体定向放射治疗的研究
Study on fractionated stereotactic radiosurgery for large intracranial metastases
梁恩顺 1佘永传1
作者信息
- 1. 210029 南京,南京医科大学附属脑科医院伽玛刀治疗中心
- 折叠
摘要
Abstract
Objective Stereotactic radiosurgery ( SRS ) delivered in 2 fractions had been employed in patients with large brain metastases ( >3 cm) as an alternative to single-fraction SRS with the aim to reduce late radiation-induced toxicity while maintaining high local control rate .This study assessed the efficacy and safety of fractionated SRS for the treatment of large brain metastases . Methods In present study , the efficacy and toxicity of multi-fraction SRS in patients with single brain metastases were evaluated .Between July 2014 and June 2015,69 patients (26 men and 43 women) with brain metastases had been treated with multi-fraction SRS.The median SRS dose was 16 Gy(range 12 to 20 Gy) in 2 fractions and the median treatment volume was 28.6 cm3(range,18-98 cm3 ) .Results With available radiographic , at a follow-up of 3 -12 months, 2 died of progressive extracranial disease .Tumor response was evaluated on contrast-enhanced T1-weighted images,and edema volume was defined as the peritumoral increased signal detected on T 2-weighted images.The local tumor control rate was 95.5%, the volume was decreased in 41 patients (61.1%).The volume was stable in 23 patients(34.3%).The volume was increased in 3 patients (4.5%) and intracranial edema was decreased in 37 patients(55.2%).Volume was unchanged in 24 cases (35.8%).Volume increased in 6 cases (8.9%) and edema control rate was 91%. Conclusion Fractionated SRS is feasible and safe in patients with large brain metastases .关键词
伽玛刀/转移瘤/立体定向放射分次治疗Key words
gamma-knife/metastases/fractionated stereotactic radiosurgery分类
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梁恩顺,佘永传..颅内巨大转移瘤分次立体定向放射治疗的研究[J].临床神经外科杂志,2018,15(3):190-192,3.
