生殖医学杂志2018，Vol.27Issue(6)：520-524,5.DOI:10.3969/j.issn.1004-3845.2018.06.004
新鲜周期卵裂胚移植策略对35～38岁患者妊娠结局的影响
Impact of fresh cleavage-stage embryo transfer policy on pregnancy outcomes in women aged 35-38 years
摘要
Abstract
Objective:To explore the impact of fresh cleavage-stage embryo transfer policy on pregnancy outcomes in women with 35-38 years old.Methods:The data of infertile women with 35-38 years old in the first fresh cleavage-stage embryo transfer cycles in the First Affiliated Hospital of Sun Yat-sen University from March to December 2015 and from March to December in 2016 were retrospectively analyzed.There were 210 fresh embryo transfer cycles from March to December 2015(group A),and 140 cycles with three embryos transferred in group A were group A1.There were 241 fresh embryo transfer cycles from March to December in 2016(group B),and 225 cycles with two transferred embryos in group B were group B1.The basic characteristics and pregnancy outcomes were compared among the groups.Results:There was no significant difference in days and doses of gonadotropin(Gn) used,the number of oocytes retrieved,the number of normal fertilization,the number of embryos available and the number of high-quality embryos between group A and B(P＞0.05).The average number of embryos transferred in group B[(1.9±0.2)] was significantly lower than that in group A[(2.6±-0.6)](P＜0.05).There were no significant differences in the implantation rate,clinical pregnancy rate,early miscarriage rate and live birth rate between groups A and B(P＞0.05).The multiple birth rate in group B(29.20％)was significantly lower than that in group A (43.64％)(P＜ 0.05).The number of oocytes retrieved and embryos available in group A1 were significantly higher than those in group B1(P＜0.05).There was no significant difference in the implantation rate,clinical pregnancy rate,early miscarriage rate and live birth rate between the two groups(P＞0.05).The multiple birth rate in group B1(30.28％)was significantly lower than that in group A1(49.38％)(P＜0.05).Conclusions:New policy of cleavage-stage embryo transfer reduced the number of embryos transferred in women with 35-38 years old in their first fresh transfer cycle,and reduced the multiple pregnancy rate,but had no significant influence on pregnancy rate and live birth rate.关键词
卵裂胚移植/新鲜周期/妊娠结局Key words
Cleavage-stage embryo transfer/Fresh embryo transfer cycles/Pregnancy outcome引用本文复制引用
刘瑜亮,周文,丁晨晖,陆宝敏,张秀冰,周灿权,徐艳文..新鲜周期卵裂胚移植策略对35～38岁患者妊娠结局的影响[J].生殖医学杂志,2018,27(6):520-524,5.基金项目
广东省科技计划项目(2016A020218008) （2016A020218008）
