天津中医药2018，Vol.35Issue(6)：419-421,3.DOI:10.11656/j.issn.1672-1519.2018.06.06
麻杏石甘汤对儿童肺炎支原体肺炎血清IL-17、TNF-α的影响
Effect of Maxing Shigan decoction on the IL-17 and TNF-αin children with mycoplasma pneumoniae pneumonia
摘要
Abstract
[Objective] To observe the clinical efficacy for the treatment of mycoplasma pneumoniae pneumonia (MPP) children and the effect on myocardial enzymes by Maxing Shigan decoction (MXSGD). [Methods] The 61 patients were randomly divided into the treat-ment group and the control group. Two groups of patients were treated with intravenous infusion of azithromycin therapy for five days, treatment group was treated with MXSGD orally 7 days.Comprehensive efficacy and the myocardial enzyme values before and after treat-ment were compared between the two group to evaluate the clinical efficacy of MXSGD. [Results] The markedly effective rate of patients between treatment group and control group was respectively 67.7%and 36.7%,whereas, the total effective rate of patients between two groups was respectively 96.8%and 90.0%,there was significant difference between the two groups (P<0.05). The clinical symptoms of pa-tients recovered significantly better in treatment group than in control group. In addition, compared with those in control group, patients in treatment group had fewer the side effects of medicine. The levels of IL-17 and TNF-α in children with MP pneumonia between two group were significantly lower after treatment than before treatment, there was significant difference (P<0.05). Furthermore, compared with those in control group, the levels of IL-17 and TNF-αin treatment group were significantly lower, there was significant difference between the two groups (P<0.05). [Conclusion] MXSGD combined with Western medicine can improve clinical symptoms and increase the total effective rate and cure rate of the children with MP pneumonia. In addition, MXSGD showed immunomodulating effect on IL-17 and TNF-α.关键词
麻杏石甘汤/肺炎支原体肺炎/儿童/白介素-17/肿瘤坏死因子-αKey words
Maxing Shigan decoction/mycoplasma pneumoniae pneumonia/children/IL-17/TNF-α分类
医药卫生引用本文复制引用
王志华,孙健,刘艳,王欣,王玉水..麻杏石甘汤对儿童肺炎支原体肺炎血清IL-17、TNF-α的影响[J].天津中医药,2018,35(6):419-421,3.基金项目
天津市卫生局科技项目(2014KZ049). （2014KZ049）
