一种可自动变形腔静脉滤器的体内评价实验
A new self-convertible inferior vena cava filter:in vivo experimental evaluation
摘要
Abstract
BACKGROUND:An inferior vena cava filter is an effective tool to prevent fatal pulmonary embolism. The existing filters have some shortcomings that limit their clinical application. OBJECTIVE:To evaluate the feasibility and capture efficiency of a new self-convertible inferior vena cava filter (SCF)in vivo. METHODS:L-lactide and ε-caprolactone were fused and polymerized to act as a degradable deformable switch of the filter. Medical stainless steel wire as the metal structure of the filter was combined with the degradable deformable switch to make the SCF. Eight SCFs were implanted into the inferior vena cava of eight adult Beagle dogs. The inferior vena cava angiography was performed to evaluate the release process, morphology and location of the filter. Venous angiography was performed 2 weeks later to evaluate the morphology and location of the filter and inferior vena cava patency. Detection of pulmonary embolism or other complications was performed at autopsy. RESULTS AND CONCLUSION:Eight SCFs were successfully implanted and positioned accurately with no tilt, and they were converted successfully at 2 weeks after the implantation, as assessed by the venous angiography. One of the eight SCFs migrated to the orifice of the right atrium, and caused asymptomatic inferior vena cava obstruction. The remaining SCFs were normally positioned with no tilt and local lesion or obstruction after deformation. No marked filling defect in the trunk of the pulmonary artery was shown by the pulmonary artery angiography. The autopsy report revealed that the filter arm had been endothelialized, and the inferior vena cava that was in contact with the filter arm had no obvious stenosis. Mild intimal hyperplasia, less than 1 mm in thickness, was found in the bottom of the filter arm, but it did not cause a stenosis in the lumen. No vena cava perforation, retroperitoneal hemorrhage, and injury of the surrounding viscera were found. Overall, the design of the SCF is feasible.关键词
下腔静脉滤器/肺栓塞/生物可降解材料/生物材料/国家自然科学基金分类
医药卫生引用本文复制引用
高喜翔,张建,谷涌泉,郭连瑞,佟铸,李立强,李建新,冯增国..一种可自动变形腔静脉滤器的体内评价实验[J].中国组织工程研究,2018,22(14):2215-2220,6.基金项目
国家自然科学基金资助项目(30972944) （30972944）
科技部国家重点研发计划(2017YFC1104100) （2017YFC1104100）
北京市医院管理局临床技术创新项目(扬帆计划XMLX201610) （扬帆计划XMLX201610）
北京市医院管理局"登峰"人才培养计划(DFL20150801) （DFL20150801）
首都卫生发展科研专项项目(首发2016-1-2012) （首发2016-1-2012）
北京市卫生系统高层次卫生技术人才培养计划学科骨干(2014-3-059) （2014-3-059）
宣武医院"英才培养计划" （）
北京市优秀人才培养青年骨干个人项目(2016000020124G108) （2016000020124G108）
北京市属医院科研培育计划(PX2018035) （PX2018035）
北京中医药科技发展资金项目(JJ2015-09) （JJ2015-09）
首都全科医学研究专项(17QK10)Funding:the National Natural Science Foundation of China, No. 30972944 （17QK10）
National Key Development Program of China, No. 2017YFC1104100 （）
Clinical Technology Innovation Project of Beijing Municipal Administration of Hospitals, No. XMLX201610 （）
Climbing Training Plan of Beijing Municipal Administration of Hospitals, No. DFL20150801 （）
Capital Health Development Research Projects, No. 2016-1-2012 （）
Beijing Health System Plan and Discipline Backbone Training for High-Level Health Technical Talents, No. 2014-3-059 （）
Talent Training Plan of Xuanwu Hospital （）
Beijing Excellent Talent Project, No. 2016000020124G108 （）
Incubating Program for Beijing Municipal Hospitals, No. PX2018035 （）
Chinese Medical Science and Technique Development Foundation Project in Beijing, No. JJ2015-09 （）
Capital Medical Research Project, No. 17QK10 （）
