心脑血管病防治2018，Vol.18Issue(3)：184-187,4.DOI:10.3969/j.issn.1009-816x.2018.03.004
丁苯酞序贯治疗并用支架成形术治疗脑梗死合并颈内动脉中重度狭窄的疗效
Effects of Butyl Phthalide Sequential Therapy and Stent-assisted Angioplasty on Patients with Cerebral Infarction Combined with Severe Stenosis of Internal Carotid Artery
摘要
Abstract
Objective To observe regional cerebral blood flow perfusionand neurological function after butyl phthalide sequential ther -apy and stent-assisted angioplasty in patients with cerebral infarction combined with severe stenosis of internal carotid artery .Methods 100 patients with moderate-severe internal carotid artery stenosis and cerebral infarction were randomly divided into observation group and control group (50 cases in each) .Butyl phthalide sequential therapy and internal carotid artery stenosis stent angioplasty was used in observation group based on the conventional treatment ,while in control group stent angioplascy was used based on the conven-tional teatment .Hospitalized patients took cranial CT and cranial magnetic resonance imaging to make a definite diagnosis of cerebral infarction .Magnetic resonance angiography (MRA) on head and neck ,carotid artery ultrasound and transcranial doppler (TCD) were used to screening intracranial blood vessels .Head CT perfusion was used in cerebral perfusion .Cerebral angiography (DSA) was used to further determine the condition of the internal carotid artery stenosis .the United States national institutes of health stroke scale (NIHSS) scores ,modified RANKIN scale (mRS) score ,BI score (life activity scale ,Barthel Index) on admission and at 2 weeks , 4 weeks and 3 months after treatment ,regional cerebral blood flow (rCBF) ,regional cerebral blood volume (rCBV) ,mean transit time (MTT) before and at 2 weeks ,4 weeks after treatment were compared .Results 100 patients were all successfully completed en-dovascular stent implantation of internal carotid artery stenosis ,50 cases accepted butyl phthalide sequential therapy . Neurological symptoms and signs were obviously improved after 2 weeks ,4 weeks and 3 months .NIHSS score ,mRS score ,BI score before treatment were no statistically significant differerent between two groups before the treatment (P> 0.05) ,which were statistically significantat 2 weeks , 4 weeks and 3 months after treatment of the two groups (P> 0.05) . Internal carotid artery stenosis was significantly lower after stent implantation .Beforethe treatment ,rCBV and rCBF in two groups had no statistical significance (P> 0 .05) ;at 2 weeks ,4 weeks after treatment in observed group ,rCBV ,rCBF were significantly higher than that of before treatment ,MTT was lower than that before treatment ,the observed group had to significant difference compaerd with the control group (P< 0 .05) .There was no obvious complications after stent implantation .Conclusions Butyl phthalide sequen-tial therapy can reduce neurologic deficits of patients with internal carotid artery stenosis and cerebral infarction ,and can ,significantly improve the degree of disability .Butyl phthalide sequential treatment therapy and stent-assisted angioplasty remarkely improve nerve function and cerebral perfusion in observed group compared with the control group .关键词
丁苯酞/序贯治疗/支架成形术/脑梗死/颈内动脉中重度狭窄Key words
Butyl phthalide/Sequential therapy/Stent-assisted angioplasty/Cerebral infarction/Moderate-severe internal carotid artery stenosis分类
医药卫生引用本文复制引用
赵小妹,周炜,孙海川,刘永刚,任翠剑,王宁,赵静,齐伟静,许云鹤,曹姗,高爱民..丁苯酞序贯治疗并用支架成形术治疗脑梗死合并颈内动脉中重度狭窄的疗效[J].心脑血管病防治,2018,18(3):184-187,4.基金项目
河北省中医药管理局科研计划项目(编号:2014328) （编号:2014328）
