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首页|期刊导航|药物分析学报(英文)|Quantification and pharmacokinetic study of tumor-targeting agent MHI148-clorgyline amide in mouse plasma using liquid chromatography-electrospray ionization tandem mass spectrometry

Quantification and pharmacokinetic study of tumor-targeting agent MHI148-clorgyline amide in mouse plasma using liquid chromatography-electrospray ionization tandem mass spectrometry

Zhijun Wang Bogdan Z. Olenyuk Jean Chen Shih Jeffrey Wang

药物分析学报(英文)2018,Vol.8Issue(3):153-159,7.
药物分析学报(英文)2018,Vol.8Issue(3):153-159,7.

Quantification and pharmacokinetic study of tumor-targeting agent MHI148-clorgyline amide in mouse plasma using liquid chromatography-electrospray ionization tandem mass spectrometry

Quantification and pharmacokinetic study of tumor-targeting agent MHI148-clorgyline amide in mouse plasma using liquid chromatography-electrospray ionization tandem mass spectrometry

Zhijun Wang 1Bogdan Z. Olenyuk 2Jean Chen Shih 3Jeffrey Wang3

作者信息

  • 1. Center for Advancement of Drug Research and Evaluation, Col ege of Pharmacy, Western University of Health Sciences, Pomona, CA 91766, USA
  • 2. Department of Pharmaceutical Sciences, Col ege of Pharmacy, Marshal B. Ketchum University, Ful erton, CA 92831, USA
  • 3. Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, Department of Cel and Neurobiology, Keck School of Medicine, USC-Taiwan Center for Translational Research, University of Southern California, Los Angeles, CA 90089, USA
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摘要

关键词

MHI148-clorgyline/HPLC/Mass spectrometry/Pharmacokinetics

Key words

MHI148-clorgyline/HPLC/Mass spectrometry/Pharmacokinetics

引用本文复制引用

Zhijun Wang,Bogdan Z. Olenyuk,Jean Chen Shih,Jeffrey Wang..Quantification and pharmacokinetic study of tumor-targeting agent MHI148-clorgyline amide in mouse plasma using liquid chromatography-electrospray ionization tandem mass spectrometry[J].药物分析学报(英文),2018,8(3):153-159,7.

基金项目

This work was supported by USC-Taiwan Center for Transla-tional Research, the Daniel Tsai Family Fund and Boyd & Elsie Welin Professorship and by the Department of Defense Prostate Cancer Research Program Grant W81XWH-12-1-0282 (to J.C. Shih and B.Z. Olenyuk). We also thank Dr. Rajesh Kota, Dr. Ramin Dubey and Dr. Ivan V. Grishagin for help in synthesizing NMI-amide and precursors and Mr. Bin Qian for assistance in animal experiments (Department of Pharmacology and Pharma-ceutical Sciences, University of Southern California, Los Angeles, CA, USA). (to J.C. Shih and B.Z. Olenyuk)

药物分析学报(英文)

OASCI

2095-1779

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