应用化学2018，Vol.35Issue(6)：645-651,7.DOI:10.11944/j.issn.1000-0518.2018.06.170214
碱促进联烯酮与丙酮二羧酸酯反应制备官能化的2-羟基间苯二甲酸酯
Synthesis of Functionalized 2-Hydroxyisophthalate via the Cascade Reactions of Allenic Ketones with Acetonedicarboxylate
摘要
Abstract
A novel methodology for the synthesis of 2-hydroxyisophthalates through cascade reactions of 1,2-allenic ketones with ethyl acetonedicarboxylate using K2 CO3 as the promoter under extremely mild conditions has been developed.Under optimal reaction conditions, a series of 2-hydroxyisophthalates derivatives were obtained with 73%~85% yield.The formation of the title compounds involves firstly a Michael addition of active methylene compounds and allenic ketone followed by its intramolecular condensation.Notable features of this protocol include simple starting materials, high yield, and easiness of handling.关键词
羟基间苯二甲酸酯/联烯酮/丙酮二羧酸酯/串联反应Key words
hydroxyisophthalate/allenic ketones/acetonedicarboxylate/cascade reaction分类
化学化工引用本文复制引用
王强,赵新萍..碱促进联烯酮与丙酮二羧酸酯反应制备官能化的2-羟基间苯二甲酸酯[J].应用化学,2018,35(6):645-651,7.基金项目
河南省教育厅科学技术研究重点项目(14A150048)资助 Supported by Natural Science Research Program from Education Department of He′nan Province(No.14A150048). （14A150048）
