应用化学2018，Vol.35Issue(6)：665-673,9.DOI:10.11944/j.issn.1000-0518.2018.06.170173
多巴胺改性海藻酸多孔支架的制备与性能
Preparation and Properties of Polydopamine and Alginate Porous Complex Scaffolds
摘要
Abstract
Alginate( Alg) is widely used in the field of tissue engineering because of its safe, non-toxic and biodegradable properties. Inspired by mussel adhesive protein, dopamine ( DA ) has excellent adhesion property and can self-oxidize to polydopamine( PDA) in weak basic buffer solution.Alg/PDA porous scaffolds were prepared by freeze-dry of Alg and PDA mixture.The results show that Alg/PDA porous scaffolds have relatively homogeneous internal structure.By changing the mass concentration of Alg, the pore size of the Alg/PDA complex scaffolds can be limited to 60~120μm, and the porosity of the scaffolds can be controlled in the range of 80%~88% which is appropriate for the growth of bond cells.The biocompatibility results indicate that the scaffolds show low cytotoxicity.关键词
多巴胺/海藻酸/多孔支架材料Key words
dopamine/alginate/porous scaffold分类
化学化工引用本文复制引用
章朱迎,陈静,俞佳蕾,赵倩,曹传昊,沈佳丽,施冬健..多巴胺改性海藻酸多孔支架的制备与性能[J].应用化学,2018,35(6):665-673,9.基金项目
江苏省高等学校大学生创新创业训练计划项目(201610295019Y)Supported by the Jiangsu Province College Students Innovation and Entrepreneurship Training Program(No.201610295019Y) （201610295019Y）
