中国人兽共患病学报2017，Vol.33Issue(8)：690-693,4.DOI:10.3969/j.issn.1002-2694.2017.08.005
阿苯达唑亚砜温敏型原位凝胶抗泡球蚴的效果
Effect of abendazole sulfoxide-loaded thermo-sensitive hydrogel on alveolar hydatid cysts
摘要
Abstract
In order to explore the effect of abendazole sulfoxide-loaded thermo-sensitive hydrogel (ABZSO/PLGA-PEG-PL-GA) on alveolar hydatid cysts,the viable protoscoleces incubated in vitro with ABZSO/PLGA-PEG-PLGA (20,40,80 μg/mL),ABZSO (40 μg/mL),PLGA-PEG-PLGA and the blank control,respectively,and the viable protoscoleces were counted.The morphological of the alveolar hydatid cysts or protoscoleces in each group were observed by scanning electron microscop(SEM).After the rats infected with alveolar hydatid cysts having been treated,the sizes of the alveolar hydatid cysts were observed.When the alveolar hydatid cysts incubated in different drug group in 18 days,the percentage of viable protoscoleces in ABZSO/PLGA-PEG-PLGA (40μg/mL) group was lower than that of ABZSO (40 μg/mL) group.Results of SEM showed that the protoscoleces in the ABZSO/PLGA-PEG-PLGA (80 μg/mL) group were seriously damaged.The in vivo study demonstrated the anti-alveolar hydatid cysts efficacy of ABZSO/PLGA-PEG-PLGA (4 mg/mL) group was better than the other groups.The anti-alveolar hydatid cysts efficacy of ABZSO/PLGA-PEG-PLGA is evident.关键词
多房棘球绦虫/泡球蚴病/阿苯达唑亚砜/温敏型原位凝胶Key words
Echinococcus multilocularis/alveolar echinococcosis/abendazole sulfoxide/thermo-sensitive hydrogel分类
医药卫生引用本文复制引用
冯祎,王芬,刘许诺,王昕,叶彬..阿苯达唑亚砜温敏型原位凝胶抗泡球蚴的效果[J].中国人兽共患病学报,2017,33(8):690-693,4.基金项目
Supported by the National Natural Science Foundation of China (Nos.30972567,81672045)国家自然科学基金(No.30972567,81672045)资助 （Nos.30972567,81672045）
