中国人兽共患病学报2017，Vol.33Issue(8)：753-756,4.DOI:10.3969/j.issn.1002-2694.2017.08.018
携带wcaG毒力基因ST19产酸克雷伯菌致白血病患者死亡的分析
Death caused by ST19 Klebsiella oxytoca with wcaG virulence gene in leukemic patient
丁慧 1章白苓 1张楠 1王小中 1胡龙华 1钟桥石 1杭亚平 1刘衍伶 1俞凤 1陈艳慧 1胡晓彦 1张黎明1
作者信息
- 1. 南昌大学第二附属医院检验科,江西省医学检验重点实验室,南昌 330006
- 折叠
摘要
Abstract
We investigated the cause of a leukemia patient induced by infect in a strain of Klebsiella oxytoca with hypermucoviscosity (HMV) phenotype.Identification and drug susceptibility of the isolate were carried out with VITEK-2 compact system.HMV phenotype was detected by string-test.The major high virulence capsular serotypes (K1,K2,K5,K20,K54 and K57) and virulence factors (rmpA,wcaG,allS,kfu,aerobactin,fimH,uge,wabG and cf29a) were detected by polymerase chain reaction and DNA sequencing.Molecular typing was performed by multilocus sequence typing (MLST).Results showed that the isolates of blood and lung tissue were Klebsiella oxytoca belonged to ST 19,which were sensitive to the antibiotics used in test,expressing the HMV phenotype.The virulence gene wcaG was found,while other virulence genes and the major high virulence capsular serotypes were negative.It indicates that ST19 Klebsiella oxytoca with wcaG virulence gene is the main reason causing leukemic patient death.关键词
产酸克雷伯菌/毒力/白血病/黏液/多位点序列分析Key words
Klebsiella oxytoca/virulence/leukemic/mucous/multilocus sequence typing (MLST)分类
医药卫生引用本文复制引用
丁慧,章白苓,张楠,王小中,胡龙华,钟桥石,杭亚平,刘衍伶,俞凤,陈艳慧,胡晓彦,张黎明..携带wcaG毒力基因ST19产酸克雷伯菌致白血病患者死亡的分析[J].中国人兽共患病学报,2017,33(8):753-756,4.
