中国现代医学杂志2017，Vol.27Issue(22)：25-29,5.DOI:10.3969/j.issn.1005-8982.2017.22.005
酰基辅酶A-胆固醇酰基转移酶在结肠癌中的表达及临床意义
Expression and clinical significance of ACAT in colon cancer
摘要
Abstract
Objective To explore the expressions and clinical significance of acyl coenzyme A-cholesterol acyltransferase 1 (ACAT1) and ACAT2 in patients with colon cancer.Methods The colon cancer,paracancerous and normal colon tissues of 60 patients with colon cancer were collected.PCR and immunohistochemical staining were used to detect the gene and protein expression levels of ACAT1 and ACAT2 in the tissues,and then SPSS20.0 was used to analyze their correlations with clinicopathological indices.Results The gene and protein expressions of ACAT1 and ACAT2 in the colon cancer tissues were higher than those in the paracancerous tissues and the normal colon tissues,and the differences were statistically significant (P ＜ 0.05).The expressions of ACAT1 and ACAT2 genes were correlated to age of the patients,Duke's stage and degree of tumor differentiation;and there was a correlation between the expressions of both genes in the colon cancer tissues (P ＜ 0.05).Conclusions ACAT1 and ACAT2 are highly expressed in colon carcinoma tissues,and their expressions are correlated to some clinical pathological characteristics such as the degree of differentiation of colon cancer and the distant metastasis.Therefore ACAT1 and ACAT2 have potential clinical significance for the early diagnosis of colon cancer.关键词
结肠癌/酰基辅酶A-胆固醇酰基转移酶/表达Key words
colon cancer/acyl coenzyme A-cholesterol acyltransferase/expression分类
医药卫生引用本文复制引用
梁慧玲,伍龙,张一桥,陈能,冯翎,蒋振旻,陈心,徐细明..酰基辅酶A-胆固醇酰基转移酶在结肠癌中的表达及临床意义[J].中国现代医学杂志,2017,27(22):25-29,5.基金项目
中央高校基本科研业务费专项基金(No:2042014kf0149) （No:2042014kf0149）
