摘要
Abstract
Objective To investigate the related factors of serum level of 17-hydroxyprogesterone (17-OHP) in neonates.Methods Totally 1,585 neonates without congenital adrenal hyperplasia who were born in the Affiliated Hospital of Southwest Medical University between January 2014 and December 2015 were enrolled for the research objects.The serum level of 17-OHP was detected by time-resolved fluoroimmunoassay,then compared among the cases with different clinical characteristics including gender,gestational age,birth weight,mode of delivery,number of fetus,time of blood sampling,blood glucose level,blood pH,presence of infection,asphyxia and hemolytic jaundice.Multiple linear regression was performed to analyze the relationships between the serum level of 17-OHP and the clinical characteristics.Results The serum 17-OHP level of all neonates was 0-136.8 nmol/L with the average level of (16.68 ± 6.83) nmol/L.The serum levels of 17-OHP in the neonates with gestational age of≤28 w,29-32 w,33-36 w,37-41 w,and ≥42 w were respectively (24.23 ± 2.18),(22.34 ± 3.23),(18.56 ± 4.54),(16.10 ±5.72) and (14.18 ± 2.56) nmol/L,there were statistically significant differences among the groups (P ＜ 0.05).The serum level of 17-OHP in the neonates with very low birth weight,low birth weight,normal birth weight and macrosomia were respectively (23.87 ± 2.25),(21.84 ± 3.36),(16.17 ± 6.08) and (14.43 ± 3.18) nmol/L,there were statistically significant differences among the groups (P ＜ 0.05).Multiple linear regression analysis showed that serum level of 17-OHP was influenced mostly by gestational age,followed by birth weight,blood pH,blood glucose,asphyxia,infection,time of blood sampling,hemolytic jaundice,mode of delivery and number of fetus (P ＜ 0.05).Conclusions Serum level of 17-OHP is influenced by gestational age,birth weight,acid-base balance,blood sugar level and other factors;therefore doctors should pay attention to these factors to comprehensively evaluate serum level of 17-OHP.关键词
17-羟孕酮/新生儿/先天性肾上腺增生/影响因素Key words
17-hydroxyprogesterone/neonate/congenital adrenal hyperplasia/related factor分类
医药卫生
