中国现代医学杂志2018，Vol.28Issue(17)：37-41,5.DOI:10.3969/j.issn.1005-8982.2018.17.007
河北地区FTO-rs9930506基因多态性与T2DM发病及认知功能的关系
FTO-rs9930506 polymorphism is associated with cognitive deficit and occurrence of type 2 diabetes in female patients of Hebei Province
摘要
Abstract
Objective To investigate the correlations of fat mass and obesity associated (FTO)- rs9930506 polymorphism with cognitive deficit and occurrence of type 2 diabetes (T2DM). Methods Totally 450 T2DM patients hospitalized in Tangshan Gongren Hospital from March 2008 to March 2010 were enrolled as the patient group, and 512 persons without T2DM were collected from a community in Beijing at the same period as the control group. RBANS was used to evaluate cognitive performance. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was applied to explore FTO-rs9930506 polymorphism. Results There was no significant difference either in allele distribution or genotype frequencies of FTO-rs9930506 locus between the patient and control groups (P > 0.05). However, significant difference was found in allele distribution between the female subjects of the two groups (P < 0.05); moreover, the subjects with G allele had 1.464 times higher risk to develop T2DM than the A allele carriers. Furhermore, BMI of the GG genotype carriers was higher than that of the AA and AG genotype carriers (P < 0.05), the language capability and delayed memory of the GG genotype carriers were worse than those of the AA and AG genotype carriers (P < 0.05). Conclusions G allele of FTO-rs9930506 locus is a risk allele for female to develop T2DM. FTO-rs9930506 polymorphism plays a role in cognitive deficit of the patients with T2DM.关键词
2型糖尿病/肥胖相关基因/多态性,单核苷酸/重复性成套神经心理状态测验/认知障碍Key words
type 2 diabetes mellitus/fat mass and obesity associated gene/polymorphism/single nucleotide/RBANS/cognition disorder分类
医药卫生引用本文复制引用
甄艳凤,周蕾,刘兴宇,房辉,田骆冰,徐刚,杨岳,孙雪玲,张鹤,许静..河北地区FTO-rs9930506基因多态性与T2DM发病及认知功能的关系[J].中国现代医学杂志,2018,28(17):37-41,5.基金项目
河北省自然科学基金(No:H2015105083) （No:H2015105083）
