中国卒中杂志2018，Vol.13Issue(6)：542-549,8.DOI:10.3969/j.issn.1673-5765.2018.06.003
住院期间他汀类药物治疗对伴有慢性肾脏病的急性缺血性卒中患者短期卒中复发的影响
Effect of Statin Use During Hospitalization on Short-term Stroke Recurrence in Acute Ischemic Stroke with Chronic Kidney Disease in Chinese Population
摘要
Abstract
Objective We investigated the effect of statin use during hospitalization in reducing short-term stroke recurrence of patients with acute ischemic stroke and chronic kidney diseases (CKD). Methods Data of first-ever ischemic stroke patients without a history of pre-stroke statin use was derived from the China National Stroke Registry (CNSR). Patients were stratified according to estimated glomerular filtration rate (eGFR): normal renal function [eGFR≥90 ml/(min·1.73 m2)], mild CKD [60 ml/(min·1.73 m2)≤eGFR<90 ml/(min·1.73 m2)] and moderate CKD [eGFR<60 ml/(min·1.73 m2)]. Multi-factors logistic regression analysis was used to evaluate the association between statin use during hospitalization and stroke recurrence with different renal functions at 3-month follow-up. Results Among 5951 patients included, 2595 (43.6%) patients were on statin use during hospitalization after stroke. Compared with non-statin group, statin use during hospitalization was associated with decreased stroke recurrence in patients with mild CKD [odds ratios (OR) 0.69, 95% confidence interval (CI) 0.50-0.95,P=0.02] and moderate CKD (OR 0.48, 95%CI 0.28-0.83,P=0.009) at 3-month follow-up, respectively. Whereas in patients with normal renal function, no significant benefit from statin therapy was detected (OR 0.80, 95%CI 0.60-1.06,P=0.12). Conclusion Statin use during hospitalization was associated with decreased stroke recurrence in ischemic stroke patients with mild and moderate CKD at 3-month follow-up, but not in patients with normal renal function in Chinese population. Further studies are needed to confirm this finding.关键词
慢性肾脏病/急性缺血性卒中/他汀类药物治疗/卒中复发Key words
Chronic kidney disease/Acute ischemic stroke/Statin therapy/Stroke recurrence引用本文复制引用
吕微,姜勇,张心邈,荆京,孟霞,周脉耕..住院期间他汀类药物治疗对伴有慢性肾脏病的急性缺血性卒中患者短期卒中复发的影响[J].中国卒中杂志,2018,13(6):542-549,8.基金项目
国家科技支撑计划项目"中国国家卒中登记研究(CNSR)"课题(2006BA101A11)国家科技支撑计划项目"重大慢病国家注册登记研究"课题(2015BAI12B02) （CNSR）
