中国卒中杂志2018，Vol.13Issue(6)：550-555,6.DOI:10.3969/j.issn.1673-5765.2018.06.004
高低频重复经颅磁刺激治疗卒中后上肢痉挛的对照研究
A Comparative Study of High and Low Frequency Repetitive Transcranial Magnetic Stimulation in Treatment of Upper Limb Spasticity after Stroke
摘要
Abstract
Objective To investigate the clinical efficacy and differences of repetitive transcranial magnetic stimulation (rTMS) for high-frequency and low-frequency stimulation in the treatment of stroke upper limb spasticity. Methods A total of 60 patients from department of neurology and physiotherapy with spasticity were randomized to receive 10 Hz (n=20), 1 Hz (n=20) or sham (n=20) rTMS. The high-frequency rTMS group and the low-frequency rTMS group were given rTMS for 40 days in the ipsilesional and contralesional primary motor cortex. The stimulation frequency of the high-frequency rTMS was 10 Hz and the stimulation intensity was 80% motor threshold (MT). The stimulation frequency of the low-frequency rTMS was 1 Hz, 90% MT; the sham stimulation group received sham stimulation. All of participants received conventional rehabilitation. All the treatments were performed once a day, 5 times per week, and continued for 8 weeks. The modified Ashworth scale (MAS), upper extremities motor function test of Fugl-Meyer movement assessment (U-FMA) and modified Barthel index (MBI) were performed before and 8 weeks after treatment. Results After treatment, there was a significant improvement of MAS U-FMA and MBI scores after treatment in three groups (P<0.01). The MAS,U-FMA and MBI scores of the low-frequency group and high-frequency group were more obviously improved than that of the control group (P<0.05), but there was no significant difference between the low frequency group and the high frequency group (P>0.05). Conclusion Low-frequency stimulation of the contralesional and high-frequency stimulation of the ipsilesional M1 area can both effectively improve the clinical symptoms and motor function of the spastic patients. There was no significant difference for their clinical efficacy.关键词
重复经颅磁刺激/卒中/上肢/痉挛/频率Key words
Repetitive transcranial magnetic stimulation/Stroke/Upper limb/Spasticity/Frequency引用本文复制引用
秦茵,刘小英,刘阅,郭小平,张长龙,张寅鑫,吴基伟,胡志宏,刘敏华,郑颖..高低频重复经颅磁刺激治疗卒中后上肢痉挛的对照研究[J].中国卒中杂志,2018,13(6):550-555,6.基金项目
福建省科技厅社会发展引导性(重点)项目(2015Y0025) （重点）
