中国卒中杂志2018，Vol.13Issue(6)：562-566,5.DOI:10.3969/j.issn.1673-5765.2018.06.006
低分子肝素预防脑出血后深静脉血栓有效性和安全性研究
Efficacy and Safety Study on Low Molecular Heparin in the Prevention for Venous Thromboembolism Prophylaxis after Spontaneous Intracerebral Hemorrhage
摘要
Abstract
Objective To assess the efficacy of low molecular weight heparin (LMWH) for deep vein thrombosis (DVT) in patients with spontaneous intracerebral hemorrhage (sICH) during early stage. Methods One hundred and four patients with sICH were enrolled in our study: LMWH group (n=51) and control group (n=53). The patients of LMWH group were injected hypodermically with LMWH (Enoxaparin Sodium Injection, 0.4 ml/d) from day 4th to day 10th after admittance. While the patients in control group received intermittent pneumatic compression (IPC). The LPA and the anticoagulant factor Xa level were detected on admission day and the treatment of low molecular heparin for the 7th day in all patients, and whether the patient had bleeding signs were observed. Results No hematoma enlargement were observed in both groups. After treatment, the serum level of LPA were significantly lower in LMWH group than that of the control group (11.74±5.30 ng/ml vs 26.81±5.12 ng/ml, P<0.05). The level of anti-Xa were significantly higher in LMWH group than that of the control group (25.96±7.97 ng/mlvs 8.06±1.32 ng/ml,P<0.05). Conclusion The hospitalized patients with acute sICH were the crowd with high risk of DVT. LMWH in doses of 0.4 ml once daily during acute phase in patients with sICH is safe and efficient.关键词
自发性脑出血/深静脉血栓形成/低分子肝素/溶血磷脂酸/抗凝血因子ⅩaKey words
Spontaneous intracerebral hemorrhage/Deep vein thrombosis/Low molecular weight heparin/Lysophosphatidic acid/Anticoagulant factor Xa引用本文复制引用
倪杰,钱健,王路娜,王芳,沙杜鹃..低分子肝素预防脑出血后深静脉血栓有效性和安全性研究[J].中国卒中杂志,2018,13(6):562-566,5.基金项目
南京市医学科技发展项目(YKK15070) （YKK15070）
