中国卒中杂志2018，Vol.13Issue(6)：573-578,6.DOI:10.3969/j.issn.1673-5765.2018.06.008
奥美拉唑预防卒中后应激性溃疡出血疗效的Meta分析
Preventive Effects of Omeprazole Against Stress Ulcer Bleeding for Post-stroke Patients: A Meta Analysis
摘要
Abstract
Objective To evaluate the preventive effects of omeprazole against stress ulcer bleeding (USB) for post-stroke patients, and compare their effectiveness between Histamine-2 receptor antagonists (H2RA). Methods Cochrane, PudMed, Embase, CNKI, WangFang and VIP were searched systematically. Case-control studies of omeprazole protects against SUB for post stroke patients were included, and the articles were performed Meta analysis by RevMan 5.2 software. Results A total of 17 case-control studies (1739 cases) were included. The results of meta-analysis were as followed: Prophylactic use of omeprazole could decrease the incidence of SUB for post-stoke patients [odds ratio (OR) 0.01, 95% confidence interval (CI) 0.06-0.14, P<0.00001]; and the treatment effectives of USB with omeprazole was better than H2RA (OR 0.24, 95%CI 0.15-0.38, P<0.00001). The use of omeprazole could decrease the mortality of post-stroke patients (OR 0.17, 95%CI 0.09-0.33, P<0.0001). Conclusion Evidence indicates that prophylactic use of omeprazole can decrease the incidence of SUB and mortality among post-stoke patients, and the effectiveness is better than H2RA.关键词
奥美拉唑/卒中/应激性溃疡出血/H2受体阻滞剂/Meta分析Key words
Omeprazole/Stroke/Stress ulcer bleeding/H2 receptor antagonist/Meta analysis引用本文复制引用
刘永辉,曾佩佩,高玉广..奥美拉唑预防卒中后应激性溃疡出血疗效的Meta分析[J].中国卒中杂志,2018,13(6):573-578,6.基金项目
广西中医药大学青年基金项目(2015MS010)广西中医基础研究重点实验室开放课题(17-259-49-08) （2015MS010）
