中华临床免疫和变态反应杂志2018，Vol.12Issue(2)：169-172,4.DOI:10.3969∕j.issn.1673-8705.2018.02.006
原发性胆汁性胆管炎血脂异常分布特点
Distribution of dyslipidemia in primary biliary cholangitis
摘要
Abstract
Objective To investigate the clinical features of dyslipidemia in patients with primary biliary cholangitis ( PBC) . To analyze the differences between patients with simple dyslipidemia and those with PBC. Methods Totally 100 PBC patients complicated with dyslipidemia ( PBC group) from Peking Union Medical College Hospital through 2010 to 2016 were enrolled, while 83 patients with simple dyslipidemia were matched by the age and gender as controls ( control group ) . The clinical features of the patients of the two groups were collected and the differences between them were evaluated. Results In PBC group, the main dyslipidemia manifested as hypercholesterolemia ( TC ) , while in the control group, low density lipoprotein ( LDL-C) was obviously increased. Compared with controls, PBC patients were more likely to had hypercholes- terolemia (14% vs. 5%, P=0. 046) and hypertriglyceridemia (19% vs. 8%, P=0. 042). The proportion of mixed hyperlipidemia in PBC group was lower than that in the control group (57% vs. 77%, P=0. 004). The levels of triglyceride (TG) [(2. 36±2. 13) mmol/L vs. (1. 57±0. 75) mmol/L, P=0. 001] and high density lipoprotein (HDL-C) [ (1. 64±0. 75) mmol/L vs. (1. 31±0. 38) mmol/L, P=0. 001] in PBC group were higher than those in the control group. In contrast, the level of LDL-C [ (3. 27±1. 22) mmol/L vs. (3. 61± 0. 69) mmol/L, P=0. 033] was lower than that in the controls. Conclusions The clinical features of dyslipidemia in PBC patients were different from those with simple dyslipidemia. Hypercholesterolemia was more common in PBC patients. The levels of TG and HDL-C were higher, while the level of LDL-C was lower in PBC patients with dyslipidemia than those with simple dyslipidemia.关键词
胆管炎,胆汁性/血脂异常/高脂血症Key words
Cholangitis/biliary/Dyslipidemia/Hyperlipidemia引用本文复制引用
邵体红,徐腾达,田然,孙金磊,张硕,曹逸涵,陈志磊,王立,张奉春..原发性胆汁性胆管炎血脂异常分布特点[J].中华临床免疫和变态反应杂志,2018,12(2):169-172,4.基金项目
首发科研专项青年项目(首发 2016-4-40111) （首发 2016-4-40111）
国家自然科学基金青年项目(81501414) （81501414）
国家自然科学基金面上项目(81571594、81771764) （81571594、81771764）
国家重点研发计划(2016YFA0101003) Capital Health Development Research Special Fund(Youth Program)(2016-4-40111) （2016YFA0101003）
National Natural Science Foundation of China(Youth Program)(81501414) （Youth Program）
National Natural Science Foundation of China(General Program)(81571594, 81771764) （General Program）
National Key Research and Development Plan(2016YFA0101003) （2016YFA0101003）
