中华临床免疫和变态反应杂志2018，Vol.12Issue(2)：187-193,7.DOI:10.3969∕j.issn.1673-8705.2018.02.010
调节性B细胞分型及其在相关疾病中的作用
Regulatory B cells: Phenotype and roles in related diseases
黄艾 1邢世杰 1聂君 1瞿越 1王建军 1江科1
作者信息
- 1. 430022 武汉,华中科技大学同济医学院附属协和医院胸外科
- 折叠
摘要
Abstract
In addition to generating antibodies, B lymphocytes also activate the immune system by producing cytokines and antigen presentation. The B lymphocytes which exert immunosuppressive function through different regulatory mechanisms, are known as regulatory B cells ( Breg) . The main mechanism of Breg's inhibitory effect is to secret interleukin ( IL) -10. Recent studies have shown that interleukin ( IL) -35 secreted by Breg cells plays an immunosuppressive role as well. It has also been suggested that Breg cells play a crucial role in maintaining the balance of natural killer ( NKT) cells in vivo. A number of Breg subpopulations have been identified through experimental and clinical studies on autoimmune diseases, which exhibit different mechanisms of immunosuppression. This article describes the latest research progress in different Breg subtypes of mice and humans and their different mechanisms of inhibition in different animal models and disease conditions.关键词
B淋巴细胞/调节性B细胞/白细胞介素10/白细胞介素35Key words
B cell/Regulatory B cell/Interleukin 10/Interleukin 35引用本文复制引用
黄艾,邢世杰,聂君,瞿越,王建军,江科..调节性B细胞分型及其在相关疾病中的作用[J].中华临床免疫和变态反应杂志,2018,12(2):187-193,7.
