中成药2017，Vol.39Issue(1)：1-6,6.DOI:10.3969/j.issn.1001-1528.2017.01.001
缩泉胶囊改善糖尿病小鼠膀胱功能
Improvement of Suoquan Capsules on bladder function of diabetic mice
摘要
Abstract
AIM To investigate the improving effect of Suoquan Capsules (Linderae Radix,Alpiniae oxyphyllae Fructus and Dioscoreae Rhizoma) on mice with diabetic cystopathy and its mechanism of action.METHODS Sixty mice were randomly assigned into normal group (n =8) and model group (n =52);the diabetic models of the latter were induced by high-fat feeding combined with streptozotocin (STZ) injection,then modeled mice (n =32) were randomly divided into model,Mecobalamin Tablets,low-and high-dose Suoquan Capsules groups.The influences of Suoquan Capsules on fasting blood glucose (FBG),glycated serum protein (GSP) level and general conditions were observed.The bladder leak point pressure (BLPP) was determined.Histopathological staining was performed on urinary bladder.And the expressions of substance P and NK1 receptor were detected by double immunofluorescent staining.RESULTS There were no significant differences in FBG,GSP,body weight,food intake and water consumption among various groups.The high-dose Suoquan Capsules significantly decreased urine volume of mice.Compared with the model group,the treatment with Suoquan Capsules markedly increased BLPP,the expressions of substance P and NK1 receptor were significantly increased,and the histopathology of bladder in mice was obviously improved.CONCLUSION Suoquan Capsules improves the diabetic cystopathy in mice,and its mechanism maybe related to the up-regulation of substance P and NK1 receptor expressions in bladder tissue.关键词
缩泉胶囊/糖尿病膀胱病变/P物质/NK1受体Key words
Suoquan Capsules/diabetic cystopathy/substance P/NK1 receptor分类
医药卫生引用本文复制引用
范平龙,连大卫,徐伟君,扶丽君,黄萍,操红缨..缩泉胶囊改善糖尿病小鼠膀胱功能[J].中成药,2017,39(1):1-6,6.基金项目
国家自然科学基金(81673676) （81673676）
