中成药2017，Vol.39Issue(1)：21-26,6.DOI:10.3969/j.issn.1001-1528.2017.01.004
桑酮碱改善2型糖尿病大鼠的糖脂代谢
Sangtongjian Mixture ameliorates glucose and lipid metabolism in type 2 diabetic rats
摘要
Abstract
AIM To observe the effects of Sangtongjian Mixture (STJ) on glucose and lipid metabolism,insulin resistance and fat cytokines in type 2 diabetic rats,and their mechanisms of action.METHODS One hundred and forty rats fed on the combination of STZ and high fat diet were established as the type 2 diabetic models.Fasting blood glucose (FBG) level reached more than 16.7 mmol/L and then the rats were randomly divided into model group,metformin (180 mg/kg) group,STJ (73.5,147 and 294 mg/kg) groups.Ten rats were set as the blank group.Each treatment group was intragastrically given the corresponding agents for twelve weeks.The fasting blood glucose levels of rats were measured once every two weeks after the administration.After a 12-week administration period,glycosylated serum protein (GSP),glycosylated hemoglobin (GHb) and lipid profile indices (TC,TG,HDL-C and LDL-C) were determined.The serum insulin level was measured by radioimmunoassay,and homeostasis model assessment of insulin resistance (HOMA-IR) and insulin sensitivity index (ISI) were calculated.The levels of serum adiponectin and leptin were detected by ELISA.RESULTS STJ remarkably decreased the levels of FBG,GSP,GHb,TC,TG,LDL-C,leptin and HOMR-IR in type 2 diabetic rats.Furthermore,STJ also significantly increased the levels of HDL-C,adiponectin and ISI.CONCLUSION STJ can improve glucose and lipid metabolism in type 2 diabetic rats by ameliorating insulin resistance and regulating fat cytokine levels.关键词
2型糖尿病/桑酮碱/胰岛素抵抗/糖脂代谢/脂联素/瘦素Key words
type 2 diabetes/Sangtongjian Mixture (STJ)/insulin resistance/glucose and lipid metabolism/adiponectin/leptin分类
医药卫生引用本文复制引用
蒯美玉,卞慧敏,马志,孙鑫,孟庆海,林超,卢颖,李育,彭国平,欧阳臻..桑酮碱改善2型糖尿病大鼠的糖脂代谢[J].中成药,2017,39(1):21-26,6.基金项目
国家自然科学基金(81072985,81573529,81373980) （81072985,81573529,81373980）
江苏高校优势学科建设工二程资助项目(PAPD) （PAPD）
