中成药2017，Vol.39Issue(1)：46-50,5.DOI:10.3969/j.issn.1001-1528.2017.01.008
清肾颗粒对慢性肾衰竭湿热证患者氧化应激的干预作用
Intervention effect of Qingshen Granules on oxidative stress in patients with chronic renal failure of damp-heat syndrome
摘要
Abstract
AIM To observe the changes of serum ROS,MDA,SOD levels in chronic renal failure (CRF) patients with damp-heat syndrome and to explore the intervention effect of Qingshen Granules (Hedyotis diffusae Herba,Salviae miltiorrhizae Radix et Rhizoma,Artemisiae scopariae Herba,etc.) on oxidative stress.METHODS Seventy cases of CRF patients with damp-heat syndrome were randomly and equally divided into control group and treatment group.Sixty cases completed the study,thirty-one cases in the treatment group,twenty-nine cases in the control group.Twenty other cases served as the normal group.The treatment group and the control group were given the basic treatment of western medicine and retention enema of TCM.The treatment group was added Qingshen Granules for eight weeks.The levels of U-Pro/24 h,Scr,BUN,estimated glomerular filtration rate (eGFR),serum ROS,MDA and SOD were measured before and after the treatment,and were compared with the normal group.RESULTS Both total effective rates on disease and on traditional Chinese medicine syndrome in the treatment group were 83.87％,significantly higher than those in the control group (51.72％ and 48.28％),respectively.The levels of U-Pro/24 h,Scr and BUN were obviously lower in the treatment group after the treatment,and eGFR was obviously higher as compared with those in the control group.Before the treatment,the levels of ROS and MDA in the treatment and control groups were significantly higher than those in the normal group,and the level of SOD was significantly lower;the levels of ROS and MDA were reduced in the treatment group after the treatment,and the level of SOD was increased;these changes in the treatment group were more significant than those in the control group.CONCLUSION Qingshen Granules can ameliorate clinical symptoms in CRF patients with damp-heat syndrome,decrease the levels of U-Pro/24 h,Scr and BUN,increase eGFR level,inhibit oxidative stress,and enhance antioxidant capacity,ultimately delay the development of renal fibrosis.关键词
慢性肾衰竭/湿热证/氧化应激/清肾颗粒Key words
chronic kidney disease/damp-heat syndrome/oxidative stress/Qingshen Granules分类
医药卫生引用本文复制引用
王亿平,章雪莲,陈芳,王东,金华,茅燕萍,吕勇,胡顺金,魏玲,刘家生..清肾颗粒对慢性肾衰竭湿热证患者氧化应激的干预作用[J].中成药,2017,39(1):46-50,5.基金项目
国家自然科学基金项目(81473673,81403372) （81473673,81403372）
安徽省自然科学基金项目(1508085MH198,1308085QH143) （1508085MH198,1308085QH143）
