中成药2018，Vol.40Issue(6)：1238-1242,5.DOI:10.3969/j.issn.1001-1528.2018.06.002
广西莪术乙酸乙酯部位的抗血栓作用
Antithrombotic effects of ethyl acetate fraction of Curcuma kwangsiensis
摘要
Abstract
AIM To study the antithrombotic effects and mechanism of ethyl acetate fraction of Curcuma kwangsiensis S.G.Lee et C.F.Liang (CKEAF).METHODS To observe the antithrombotic effects of CKEAF on tail thrombotic mouse models and arteriovenous bypass thrombotic rat models induced by carrageenan,and in vivo thrombosis rat models induced by FeCl3.The serum levels of ET-1,6-keto-PGF1α,TXB2 in rats were measured by enzyme linked immunosorbent assay (ELISA),and the level of NO was determined by nitrate reductase method.Rat models of acute blood stasis were further established for hemorheological study.RESULTS CKEAF significantly decreased the number and length of blackened thrombotic tail of carrageenan-treated mice.Rat models shared significant wet weight loss in arteriovenous bypass thrombosis and in vivo thrombosis,increased levels of NO,6-keto-PGF1α,decreased levels of ET-1,TXB2,and decreased whole blood and plasma viscosity (rats of acute blood stasis model).CONCLUSION Significant antithrombotic effects by CKEAF may contribute to elevated levels of NO,6-keto-PGF1α,and decreased levels of ET-1,TXB2,and lowered whole blood and plasma viscosity.关键词
广西莪术/乙酸乙酯部位/抗血栓作用/血液流变学Key words
Curcuma kwangsiensis S.G.Lee et C.F.Liang/ethyl acetate fraction/antithrombotic effects/hemorheology分类
医药卫生引用本文复制引用
陈晓军,韦洁,蒋珍藕,农云开,李燕婧,严克俭..广西莪术乙酸乙酯部位的抗血栓作用[J].中成药,2018,40(6):1238-1242,5.基金项目
广西自然科学基金项目(2013GXNSFAA019262) （2013GXNSFAA019262）
