中成药2018，Vol.40Issue(6)：1253-1258,6.DOI:10.3969/j.issn.1001-1528.2018.06.005
复方鹿角霜浸膏对佐剂性关节炎大鼠的抗炎作用
Anti-inflammatory effects of compound Cervi Cornu Degelatinatum extract on adjuvant arthritic rats
摘要
Abstract
AIM To study the anti-inflammatory effects of compound Cervi Cornu Degelatinatum extract on adjuvant arthritic rats.METHODS The rats,except for those assigned into a blank group,were induced to be the adjuvant arthritis models by Freund's complete adjuvant and randomly divided into model group,Prednisone Acetate Tablets group,Tripterygium wilfordii polyglycoside tablets group,and compound Cervi Cornu Degelatinatum extract groups (1 000 mg/kg high-dose group,500 mg/kg medium-dose group,and 250 mg/kg low-dose group) to observe changes in body weight,mental state,and extent of joints injury.Post-treatment levels of TNF-α,IL-6,IL-10 and PGE-2 were determined by ELISA,and the pathological changes of ankle joints were assessed by HE staining.RESULTS Significantly lower body weight and IL-10 level,markedly higher levels of TNF-α,IL-6,PGE-2,and joints injury in the model group than those in the blank group were observed (P ＜0.01).Such indices also revealed the significant superiority in the high-dose,medium-dose groups of compound Cervi Cornu Degelatinatum extract and the positive control group as compared with the model group.CONCLUSION Compound Cervi Cornu Degelatinatum extract highlights the rheumatoid arthritis management through proinflammatory cytokines secretion reduction,the antiinflammatory factors improvement,and the inflammatory reaction and tissue damage alleviation.关键词
复方鹿角霜浸膏/类风湿关节炎/佐剂性关节炎/抗炎作用/细胞因子Key words
compound Cervi Cornu Degelatinatum extract/rheumatoid arthritis/adjuvant arthritis/anti-inflammatory effects/cytokines分类
医药卫生引用本文复制引用
罗尚文,王燕燕,张学农,韩师师..复方鹿角霜浸膏对佐剂性关节炎大鼠的抗炎作用[J].中成药,2018,40(6):1253-1258,6.基金项目
国家“新药创制”科技重大专项项目(2011ZX09102-006-05) （2011ZX09102-006-05）
国家自然科学基金资助项目(30970297) （30970297）
湖北省中医药中西医结合科研项目(2016～201765-5) （2016～201765-5）
