中成药2018，Vol.40Issue(6)：1266-1270,5.DOI:10.3969/j.issn.1001-1528.2018.06.007
脉络舒通颗粒联合西药对血栓性浅静脉炎患者的临床疗效
The combinative therapeutic effects of Mailuo Shutong Granules and synthetic medications on patients with superficial thrombophlebitis
摘要
Abstract
AIM To observe the combinative therapeutic effects of Mailuo Shutong Granules and routine synthetic medications on patients with superficial thrombophlebitis (STP).METHODS Seventy patients randomly and equally divided into control group and observation group were subjected to a two-week conventional treatment and a two-week intervention of Mailuo Shutong Granules on the basis of routine treatment,respectively,and they had the before and after the treatment assessment in terms of main clinical symptoms and signs,endothelial function indices (NO,ET-1,TXB2,6-Keto-PGF1α,VEGF,vWF),hemorheology indices (plasma viscosity,blood sedimentation,erythrocyte aggregation index,fibrous protein).RESULTS The observation group generally demonstrated significantly higher effective rate than the control group (P ＜ 0.05).Markedly decreased post-treatment scores for main clinical symptoms and signs,TXB2,ET-1,vWF,plasma viscosity,blood sedimentation,erythrocyte aggregation index,fibrous protein,and increased 6-Keto-PGF1 α,VEGF and NO (P ＜ 0.05) in both groups were observed,as well as the between-group variance showing the observation group's priority (P ＜ 0.05).The respective 8.57％ and 14.29％ incidence rates of adverse reactions in the observation group and control group were also noticed.CONCLUSION For patients with STP,a combination therapy of Mailuo Shutong Granules on the basis of synthetic medications contributes to an effective main clinical symptoms alleviation due to its vascular endothelial cells protection,cellular secretion function and hemorheological improvement.关键词
脉络舒通颗粒/西药/血栓性浅静脉炎(STP)Key words
Mailuo Shutong Granules/synthetic medications/superficial thrombophlebitis (STP)分类
医药卫生引用本文复制引用
李亚南,刘小勇,宋兆华..脉络舒通颗粒联合西药对血栓性浅静脉炎患者的临床疗效[J].中成药,2018,40(6):1266-1270,5.基金项目
河南省中医药科学研究专项课题(2015ZY02017) （2015ZY02017）
