中成药2018，Vol.40Issue(6)：1278-1282,5.DOI:10.3969/j.issn.1001-1528.2018.06.010
黄连香薷饮中4种成分在大鼠血浆中的药动学行为
Pharmacokinetic behaviors of four constituents in Huanglian Xiangru Decoction in rat plasma
摘要
Abstract
AIM To investigate the pharmacokinetic behaviors of four constituents in Huanglian Xiangru Decoction in rat plasma.METHODS The rats intragastrically administered with diluted drug (9 g/kg) had their blood collected for the determination of plasma concentration by HPLC,after which pharmacokinetic parameters were calculated by 3p97 software.RESULTS The plasma concentration-time curves for berberine hydrochloride,apigenin,honokiol,magnolol accorded with open one compartment model,with the Tpeak values of (1.436 5 ± 0.311 9),(2.049 5 ±0.705 5),(1.359 0 ±0.343 4),(1.195 9 ±0.334 6) h,AUC values of (1.477 8 ± 0.4840),(1.063 0±0.452 1),(0.863 5±0.2697),(7.0105 ±2.584 7) μg/(mL· h),Cmax values of (0.245 9 ±0.019 4),(0.129 6 ±0.016 7),(0.180 9 ±0.021 3),(0.966 7 ±0.042 0) μg/mL,respectively.CONCLUSION Compared with the other three constituents in Huanglian Xiangru Decoction,magnolol demonstrates better in vivo absorption and higher bioavailability.关键词
黄连香薷饮/盐酸小檗碱/芹菜素/和厚朴酚/厚朴酚/药动学行为/血浆/HPLCKey words
Huanglian Xiangru Decoction/berberine hydrochloride/apigenin/honokiol/magnolol/pharmacokinetic behaviors/plasma/HPLC分类
医药卫生引用本文复制引用
吴巧凤,严云良,鲁银均..黄连香薷饮中4种成分在大鼠血浆中的药动学行为[J].中成药,2018,40(6):1278-1282,5.基金项目
国家自然科学基金(81473335/H2803,81274030/H2803) （81473335/H2803,81274030/H2803）
浙江省自然科学基金(LY15H290003/Y18H280023) （LY15H290003/Y18H280023）
浙江省重中之重一级学科“中药学”建设-浙江中医药大学开放基金(Yao2016015) （Yao2016015）
