中成药2018，Vol.40Issue(6)：1329-1335,7.DOI:10.3969/j.issn.1001-1528.2018.06.021
翼首草化学成分及其神经保护活性
Chemical constituents from Pterocephalus hookeri and their neuroprotection activities
李公权 1盛东来2
作者信息
- 1. 上海市宝山区精神卫生中心,上海 201900
- 2. 杭州师范大学,杭州师范大学发育与再生研究所,浙江杭州 310036
- 折叠
摘要
Abstract
AIM To study the chemical constituents from Pterocephalus hookeri (C.B.Clarke) Hoeck and their neuroprotection activities.METHODS The 95％ ethanol extract from P.hookeri was isolated and purified by Sephadex LH-20,DM-130 macroporous resin,silica and HPLC,then the structures of obtained compounds were identified by physicochemical properties and spectral data.The neuroprotection activities were studied by establishment of Parkinson's disease model of genetically modified zebrafish.RESULTS Nine compounds were isolated and identified as triplostoside A (1),cantleyoside (2),sylvestroside Ⅰ (3),sylvestroside Ⅲ dimethyl acetal (4),sylvestroside Ⅲ (5),laciniatoside Ⅰ-7-dibutyl acetal (6),laciniatoside Ⅰ (7),laciniatoside Ⅱ (8),sylvestroside Ⅳ (9).The n-BuOH fraction of P.hookeri had good performance on neuroprotection in hydrogen peroxide model.CONCLUSION Compound 4 is isolated from this plant for the first time.P.hookeri has neuroprotection activities.关键词
翼首草/化学成分/结构鉴定/神经保护活性Key words
Pterocephalus hookeri (C.B.Clarke) Hoeck/chemical constituents/isolation and identification/neuroprotective activities分类
医药卫生引用本文复制引用
李公权,盛东来..翼首草化学成分及其神经保护活性[J].中成药,2018,40(6):1329-1335,7.
