摘要
Abstract
Objective To study the related factors influencing the long-term prognosis of chemotherapy combined with radiotherapy after surgery for breast cancer. Methods One hundred and seventy-four patients who underwent radical mastectomy in the hospital from January 2012 to January 2015 were selected. All of them were treated by chemotherapy combined with radiotherapy after surgery. The clinicopathological data of patients such as age, menstrual status, tumor diameter, lymph node status, tumor location, pathological type, family history of cancer, estrogen receptor, progesterone receptor and expression of proto-oncogene human epidermal growth factor receptor 2 ( HER2) were collected. All patients were followed up for 3 years. The patients were grouped with tumor recurrence or death as the endpoint. Patients with disease-free survival ( DFS)≤3 years were included in the poor prognosis group, and patients with DFS>3 years were included in the good prognosis group. The clinicopathological data were compared between the two groups. Results In 174 patients, 166 cases were followed up effectively, including 24 cases with recurrence and 6 death cases. The rate of poor prognosis was 18. 1％. The proportions of patients older than 40 years old, with tumor diameter shorter than 2 cm, without lymph node metastasis, with non-invasive cancer, estrogen receptor positive, progesterone receptor positive and HER2 negative patients in the good prognosis group were significantly higher than those in the poor prognosis group ( P<0. 05) . Conclu-sion Age, tumor diameter, lymph node status,pathological type, estrogen receptor, progesterone receptor and expression of HER2 have significantin fluence on the prognosis of patients with breast cancer.关键词
乳腺癌/根治性手术/放射治疗/化学药物治疗/预后因素Key words
Breast cancer/Radical surgery/Radiotherapy/Chemotherapy/Prognostic factor分类
医药卫生
