转化医学杂志2018，Vol.7Issue(3)：159-166,8.DOI:10.3969/j.issn.2095-3097.2018.03.010
益生菌制品对血脂水平干预疗效的Meta分析
Efficacy of probiotic products on serum lipid profiles:a meta-analysis
王力 1朱智明 2沈雅庭 1刘彦波 1方志荣1
作者信息
- 1. 316000 浙江舟山,中国人民解放军第413医院内二科
- 2. 100048 北京,中国人民解放军海军总医院心脏中心
- 折叠
摘要
Abstract
Objective To evaluate the efficacy of probiotic products on human serum lipid profiles, we conducted a meta-analysis. Methods Randomized, controlled clinical trials relating to interventional studies of probiotic products on human serum lipid profiles were obtained by search of electronic databases, such as PubMed, Cochrane Library, Web of Science, EMBASE, Chinses Pe-riodical Full Text Database, Wanfang Database, Full Text Database of Chinese Sci-Tech Periodical. Statistical analysis was performed with Review Manager 5. 3. 3. Results Eighteen randomized con-trolled trials were analyzed in our study. Meta-analysis results showed that the serum total cholesterol [mean difference(MD)=-0. 2 mmol/L, 95％ confidence intervals(CI): -0. 28— -0. 12 mmol/L] and low-density lipoprotein cholesterol ( MD=-0. 19 mmol/L, 95％CI:-0. 26 —-0. 13 mmol/L) were significantly decreased ( P<0. 00001) in probiotic intervention group compared with the placebo group, while high-density lipoprotein cholesterol and triglyceride had no significant differ-ence ( P>0. 05) . Patients with hyperlipidemia, overweight ( body weight index was 25—29. 9 kg/m2), receiving long-term intervention duration (>4 weeks) and intestinal micro-ecologic products got more benefit. Conclusion The probiotic products were effective in down-regulating the serum total cholesterol and low-density lipoprotein cholesterol levels in dyslipidemia patients and healthy in-dividuals. It is expected to be used in the primary and secondary prevention of atherosclerotic cardio-vascular diseases in patients with dyslipidemia.关键词
高脂血症/益生菌/随机对照试验/Meta分析Key words
Hyperlipidemias/Probiotics/Randomized controlled trials/Meta-analysis分类
医药卫生引用本文复制引用
王力,朱智明,沈雅庭,刘彦波,方志荣..益生菌制品对血脂水平干预疗效的Meta分析[J].转化医学杂志,2018,7(3):159-166,8.
