中国现代中药2017，Vol.19Issue(8)：1089-1090,1096,3.DOI:10.13313/j.issn.1673-4890.2017.8.007
通体结香技术产沉香的提取物灌胃KM小鼠的急性毒性研究
Acute Toxicity Study of Extracts from Agarwood
摘要
Abstract
Objective:To study the acute toxicity of KM mice by gavage excess extracts of agarwood produced by Agar-Wit.Methods:The agarwood extracts were administered by intragastric administration (ig) to KM mice at the maximum daily dose,toxicity symptoms and mortality were observed and recorded.The main organs of mice,dissected after 14 days,were examined by the unaided eye.Results:The mice were all not observed obvious poisoned symptom and death with the acute toxicity test in 40 g · kg-1 dose,and no obvious diversity (P ＞ 0.05) was found by comparing the negative control group in weight of the mice,also no abnormal condition for the pathologic examination of main organs.Conclusion:No apparent subchronic toxicity could be observed in mice after ig agarwood extracts.Agarwood produced by Agar-Wit oral dose commonly used in clinical treatment is safe.关键词
沉香/提取物/最大给药量/急性毒性Key words
Agarwood/extracts/maximum daily dose/acute toxicity引用本文复制引用
刘洋洋,田树红,冯剑,杨云,魏建和..通体结香技术产沉香的提取物灌胃KM小鼠的急性毒性研究[J].中国现代中药,2017,19(8):1089-1090,1096,3.基金项目
海南省重大科技计划项目(ZDKJ2016004) （ZDKJ2016004）
国家自然科学基金项目(8143055) （8143055）
中国医学科学院医学与健康科技创新工程项目(2016-I2M-2-003) （2016-I2M-2-003）
中组部万人计划(99950534) （99950534）
