中国现代中药2017，Vol.19Issue(8)：1091-1096,6.DOI:10.13313/j.issn.1673-4890.2017.8.008
沉香醇提物对四氯化碳致小鼠急性肝损伤的保护作用
Protective Effects of Alcohol Extract of Agarwood on Acute Liver Injury Induced by Carbon Tetrachloride in Mice
摘要
Abstract
Objective:This study is aimed to investigate the hepatoprotective effect of alcohol extract of agarwood on acute liver injury induced by carbon tetrachloride (CCl4) in mice.Methods:Mice were injected with CCl4 to establish acute liver injury model.Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were measured of serum.The myeloperoxidase (MPO),nitric oxide (NO),total peroxide (T-AOC) and superoxide dismutase (SOD) of the liver tissue homogenate were measured,and observed degree of liver injury by pathological sections.The interleukin-1β (IL-1β) and Interleukin-10 (IL-10) expression levels were measured by enzyme-linked immunosorbent assay (ELISA).Results:Compared with the model group,the alcohol extract of Agar-Wit agarwood groups significantly decreased the activities of serum ALT,AST,MPO and NO contents as well as the expression level of IL-1β,enhanced the capacity of T-AOC,the activity of SOD and IL-10 level,and improved pathological injury of liver tissue,especially the alcohol extract of Agar-Wit agarwood 2.84 g/kg group.Conclusion:Alcohol extracts of agarwood show a significantly protective effect on acute liver injury in mice,and its mechanism may be related to anti-oxidative stress,inhibition of lipid peroxidation and anti-inflammatory effect.关键词
沉香醇提物/四氯化碳/急性肝损伤/抗氧化损伤/抗炎Key words
Alcohol extracts of agarwood/Carbon tetrachloride/Acute liver injury/Anti-oxidant/Anti-inflammatory引用本文复制引用
王灿红,王帅,彭德乾,刘洋洋,郭鹏,魏建和..沉香醇提物对四氯化碳致小鼠急性肝损伤的保护作用[J].中国现代中药,2017,19(8):1091-1096,6.基金项目
海南省重大科技计划项目(ZDKJ2016004) （ZDKJ2016004）
海南省自然科学基金(817290) （817290）
国家自然科学基金资助项目(81673545) （81673545）
中组部“万人计划”(99950534) （99950534）
