癌变·畸变·突变2018，Vol.30Issue(3)：226-229,4.DOI:10.3969/j.issn.1004-616x.2018.03.012
降扎乡高氡温泉周围居民血浆中8-羟基脱氧鸟苷和硫氧还蛋白还原酶水平的研究
The level of 8-0HdG and TrxR in the plasma of residents around the radon hot springs in Jiangzha township
高延晓 1田梅 1高刚 1刘建香1
作者信息
- 1. 中国疾病预防控制中心辐射防护与核安全医学所,辐射防护与核应急中国疾病预防控制中心重点实验室,北京100088
- 折叠
摘要
Abstract
OBJECTIVE:To investigate the effects of long-term and repeatedly exposure to radon from hot spring on oxidative damage and antioxidation in the population.METHODS:A simple random sampling method was used to select 38 residents around radon hot spring in Jiangzha township as high radon group,and 39 residents of Axirong township were selected as control group.The levels of 8-hydroxydeoxyguanosine (8-OHdG) and thioredoxin reductase (TrxR) in plasma of the two groups were measured by enzyme-linked immune sorbent assay (ELISA).The Mann-Whitney U test was used to compare the differences in 8-OHdG and TrxR between the two groups.Questionnaire surveys were conducted on residents' cognition of radon.RESULTS:Levels of 8-OHdG in peripheral plasma of residents with high radon group were significantly decreased and levels of TrxR were significantly increased (Z=-3.316,-3.773,P＜0.05),which were 0.571 and 2.325 times that of the control group respectively.Radon exposure was associated with differential expression of 8-OHdG and TrxR (P＜0.05).In addition,the two groups of residents lacked knowledge about radon and its impact on human health and about measures to reduce it.CONCLUSION:Long-term and repeatedly exposure to radon from hot springs enhanced body's antioxidant capacity to a certain extent,and reduced the level of oxidative damage.Local residents had a serious lack of awareness of radon,and they should be educated about such knowledge.关键词
氡/低剂量电离辐射/8-羟基脱氧鸟苷/硫氧还蛋白还原酶Key words
radon/low dose radiation/8-hydroxy-2-deoxyguanosine/thioredoxin reductase分类
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高延晓,田梅,高刚,刘建香..降扎乡高氡温泉周围居民血浆中8-羟基脱氧鸟苷和硫氧还蛋白还原酶水平的研究[J].癌变·畸变·突变,2018,30(3):226-229,4.
