重庆医学2018，Vol.47Issue(17)：2290-2293,2297,5.DOI:10.3969/j.issn.1671-8348.2018.17.009
儿童过敏性哮喘患者中Th17/Treg比值与IDO相关性的研究
Study on the correlation between Th1T/Treg ratio and IDO in children with allergic asthma
摘要
Abstract
Objective To demonstrate that IDO may be involved in the development of allergic asthma in children by affecting Th1T/Treg differentiation and its related cytokines.Methods Thirty-three children over 5 years old who were diagnosed the first time with allergic asthma were selected from the pediatric outpatient department.Another 33 healthy children were selected as the controls.Pulmonary function test,skin prick test,eosinophil count were taken.Peripheral blood was collected to measure the number and percentage of Th17 and Treg cells and the levels of cytokines,including IL-10,IL-17,IL-6 and TGF-β.Venous blood and induced sputum were used to detect the concentration of tryptophan and kynureninein IDO metabolites.Results Compared with the control group,there was a significant Th17/Treg imbalance in the asthma group,IL-17,IL-6 levels were significantly increased,TGF-β,IL-10 levels were significantly reduced,IDO levels were significantly reduced,and its levels were negativly associated with Th17/Treg ratio.Conclusion In children with allergic asthma,IDO may stimulate the production of IL-10,inhibit the expression of IL-6,upregulate the level of Treg,and lead to the imbalance of Th17/Treg;Therefore,IDO may be a molecular "switch" that leads to the conversion of Th17 cells to Treg cells,which plays a potentially protective role in the pathogenesis of asthma.关键词
吲哚胺2,3双加氧酶/Th17/Treg/IL-10/IL-6/哮喘Key words
indoleamine 2,3-dioxygenase/T-lymphocytes, regulatory/IL-10/IL-6/asthma分类
医药卫生引用本文复制引用
胡影,陈志强,金玲,王梅,廖伟..儿童过敏性哮喘患者中Th17/Treg比值与IDO相关性的研究[J].重庆医学,2018,47(17):2290-2293,2297,5.基金项目
国家自然基金面上项目(30500231) （30500231）
第三军医大学第一附属医院院管课题(SWH2015LC11 （）
SWH2016LCYB-15). （）
