化学工程2018，Vol.46Issue(5)：28-32,5.DOI:10.3969/j.issn.1005-9954.2018.05.006
基于模型的银杏叶提取物冷冻干燥优化的研究
Ginkgo extracts lyophilization process optimization based on model
高兴 1刘代春 2康青 1李雄 1于颖1
作者信息
- 1. 中国药科大学 工学院,江苏南京210009
- 2. 楚天科技股份有限公司,湖南长沙410600
- 折叠
摘要
Abstract
In order to optimize the Ginkgo extracts lyophilization technology,the heat and mass transfer mathematical model were established and simplified,and the dry layer resistance coefficient and heat transfer coefficient was also obtained through experiment.The lyophilization simulation was carried out at the shelf temperature-40--15 ℃,chamber pressure 2-40 Pa and the sublimating dry time limits in 100 hours.The simulation results show that the lower the chamber pressure is,the shorter the sublimation drying time is,and the higher the shelf temperature is,the shorter the sublimation drying time is.Moreover,when the shelf temperature is low,the change of chamber pressure affects the sublimating dry time significantly,but when the shelf temperature is high,the change of chamber pressure affects the sublimating dry time less.Based on the results of simulation and the freeze-drying microscopy experiment,the optimum operation parameter were ensured as:chamber pressure is 8 Pa,the shelf temperature is-32 ℃.According to this parameter,the validity experiment is performed,and the product performance from experiment is good.The comparision results between experiments and simulation show that the simplified mathematical model is correct to simulate the lyophilization process to forecast the Ginkgo extracts sublimating drying time and give the optimum technology parameter.The simplified mathematical model can be applied in the other drug lyophilization process.关键词
银杏叶提取物/冷冻干燥/传热传质模型/过程模拟/工艺参数优化Key words
Ginkgo extracts/lyophilization/heat and mass transfer model/process simulation/technology parameter optimization分类
通用工业技术引用本文复制引用
高兴,刘代春,康青,李雄,于颖..基于模型的银杏叶提取物冷冻干燥优化的研究[J].化学工程,2018,46(5):28-32,5.
