药物性肝损伤的诊断和治疗OA北大核心CSTPCD
Diagnosis and treatment of drug-induced liver injury
由于缺乏特异性生物标志物,药物性肝损伤(DILI)的诊断主要依赖排除法.其一是因果关系评估量表,以RUCAM量表应用最广,相对客观,但需适当改进.其二是总体判断法(专家观点法),带有明显的主观性,临床常用的是简化总体判断法;美国DILI网络采用的结构化专家观点程序法因费时费力而无法在临床上常规应用.药物再刺激试验(DRT)阳性是DILI临床诊断的金标准,但药物再刺激试验阴性不能排除DILI.淋巴细胞转化试验(LTT)、改良LTT、单核细胞源性肝细…查看全部>>
Due to a lack of specific biomarkers, the diagnosis of drug -induced liver injury (DILI) mainly depends on the method of exclusion.The Roussel Uclaf Causality Assessment Method (RUCAM) scale is the most widely used causality assessment scale and is relatively objective, but it is still waiting for further improvement.Another method is global introspection or expert opinion , which is relatively subjective,and the simplified global introspection method is com…查看全部>>
于乐成;范晔;陈成伟
南京中医药大学附属八一医院全军肝病中心,南京210002南京中医药大学附属八一医院全军肝病中心,南京210002中国人民解放军第八五医院上海临床肝病研究中心,上海200235
医药卫生
药物性肝损伤诊断治疗
drug -induced liver injurydiagnosistherapy
《临床肝胆病杂志》 2018 (6)
1160-1165,6
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