临床肝胆病杂志2018，Vol.34Issue(6)：1259-1263,5.DOI:10.3969/j.issn.1001-5256.2018.06.025
乌鲁木齐市维吾尔族急性缺血性脑梗塞合并非酒精性脂肪性肝病患者的临床分析
A clinical analysis of Uygur patients with acute ischemic cerebral infarction complicated by nonalcoholic fatty liverdisease in Urumqi, China
摘要
Abstract
Objective To investigate the association between acute ischemic cerebral infarction (AICI) and nonalcoholic fatty liver disease (NAFLD) in Uygur patients in Urumqi, China and possible risk factors.Methods A retrospective analysis was performed for the clinical data of 294 Uygur patients with AICI who were admitted to The Second Affiliated Hospital of Xinjiang Medical University from September 2011 to July 2017, and according to the diagnosis based on abdominal ultrasound , these patients were divided into case group with 110 patients (AICI complicated by NAFLD) and control group with 184 patients (without NAFLD).The two groups were observed in terms of general information, biochemical parameters, and intima -media thickness (IMT) of the common carotid artery.The AICI patients were divided into ≤30 years group, 31 -45 years group, 46 -60 years group, 61 -75 years group, and ≥60 years group according to age, and the incidence rate of NAFLD was compared between these groups .The t -test was used for comparison of continuous data between groups , the chi -square test was used for comparison of categorical data between groups , and a multivariate logistic regression analysis was performed .Results Compared with the control group, the case group had significantly higher age , body mass index, waist -hip ratio, HbA1c, fasting blood glucose, uric acid, alanine aminotransferase (ALT), gamma -glutamyl transpeptidase, triglyceride (TG), total cholesterol, and low -density lipoprotein cholesterol (LDL -C) and a significantly lower aspartate aminotransferase level (t =9.814, 5.569, 8.139, 3.592,3.514, 15.703, 15.113, 8.092, 10.834, 7.719, 11.481, and 7.561, all P <0.05).The case group had a significantly higher propor - tion of the patients with a smoking history than the control group (χ2 =14.060, P <0.05).The logistic regression analysis showed that the increases in age (odds ratio [OR] =1.301, 95% confidence interval [CI]: 1.065 -1.589, P <0.05) and serum levels of ALT (OR = 1.383, 95% CI: 1.059 -1.805, P <0.05), TG (OR =1.335, 95% CI: 1.091 -1.634, P <0.05), and LDL -C (OR =1.358, 95% CI: 1.125 -1.639, P <0.05) and a smoking history (OR =1.423, 95% CI: 1.105 -1.833, P <0.05) were closely associated with NAFLD in AICI patients.The incidence rate of NAFLD in AICI patients increased with age , and there was a significant difference between different age groups (χ2 =13.558, P =0.009); the 61 -75 years group and the >76 years group had an incidence rate of NAFLD of 44.09% and 51.35%, respectively, which were significantly higher than that in the other three groups (P <0.05).Conclusion Increases in age and serum levels of ALT, TG, and LDL -C and a smoking history are independent risk factors for NAFLD in patients with AICI , and AICI patients aged over 60 years have a high incidence rate of NAFLD.关键词
非酒精性脂肪性肝病/脑梗死/维吾尔族Key words
nonalcoholic fatty liver disease/brain infarction/uygur nationality分类
医药卫生引用本文复制引用
陈芹芹,梁灿灿,杨丽君,孟清,丁永年..乌鲁木齐市维吾尔族急性缺血性脑梗塞合并非酒精性脂肪性肝病患者的临床分析[J].临床肝胆病杂志,2018,34(6):1259-1263,5.基金项目
新疆医科大学科技创新基金项目(XJC201361) （XJC201361）
