临床肝胆病杂志2018，Vol.34Issue(6)：1277-1281,5.DOI:10.3969/j.issn.1001-5256.2018.06.029
我国吡咯烷生物碱致肝窦阻塞综合征的临床特征分析
Clinical features of sinusoidal obstruction syndrome induced by pyrrolidine alkaloids in China
郭严 1张世荣 1文良志 1刘凯军 1胡辂 1孙文静 1王斌 1魏艳玲 1陈东风1
作者信息
- 1. 陆军军医大学附属第三医院消化内科,重庆400035
- 折叠
摘要
Abstract
Objective To investigate the clinical manifestations, treatment, and prognosis of sinusoidal obstruction syndrome induced by pyrrolidine alkaloids in China.Methods Related databases were searched, and 107 articles on sinusoidal obstruction syndrome published from January 1980 to April 2017 in China were included, with 407 patients in total.Related data of this disease were analyzed , including sex, age, regional distribution, clinical manifestations, imaging and pathological findings, and prognosis.Results The male/female ratio of 407 patients was 1:1.22, and the age of onset ranged from 13 months to 81 years.Major clinical manifestations included abdominal dis - tension, abdominal pain, ascites, and hepatomegaly.The most typical abdominal CT findings were hepatomegaly and a map -like or patchy change after enhancement.Pathological examination showed sinusoidal expansion and congestion and varying degrees of stenosis of small he - patic veins.Of all 407 patients, 302 had response and 90 died, resulting in a mortality rate of 22.1%.Conclusion In China, the male population has a higher incidence rate of sinusoidal obstruction syndrome than the female population , and sinusoidal obstruction syndrome can occur at any age.Major clinical manifestations include abdominal distension , abdominal pain, ascites, and hepatomegaly, which can be used to make a definite diagnosis in combination with typical liver CT manifestations .Pathological findings by liver biopsy are the gold stand - ard for diagnosis.Symptomatic treatment is the major treatment modality, and some patients may have poor prognosis .关键词
肝静脉闭塞性疾病/吡咯烷类/中国Key words
hepatic veno-occlusive disease/pyrrolidines/China分类
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郭严,张世荣,文良志,刘凯军,胡辂,孙文静,王斌,魏艳玲,陈东风..我国吡咯烷生物碱致肝窦阻塞综合征的临床特征分析[J].临床肝胆病杂志,2018,34(6):1277-1281,5.
