临床肝胆病杂志2018，Vol.34Issue(6)：1325-1328,4.DOI:10.3969/j.issn.1001-5256.2018.06.041
肠道菌群-脂多糖-Toll样受体4轴与肝细胞癌的关系
The association between the intestinal microbiota -lipopolysaccharide -Toll -like receptor 4 axis and hepatocellularcarcinoma
摘要
Abstract
Hepatocellular carcinoma is the major complication of various end -stage chronic liver diseases.Studies have shown that intestinal barrier injury and intestinal flora disturbance are commonly seen in patients with liver diseases , which may cause intestinal bacterial translocation and endotoxemia.Toll -like receptor 4 (TLR4) is a pattern recognition receptor in the liver and can bind to lipopolysaccharide (LPS), the active ingredient of endotoxin, result in immune inflammatory response via various signal transduction pathways , and finally promote hepatic fibrosis and tumorigenesis.This article reviews the intestinal microbiota -LPS -TLR4 axis and the pathogenesis of hepatocellu - lar carcinoma.关键词
癌,肝细胞/肠杆菌科/脂多糖类/Toll样受体4/综述Key words
carcinoma/hepatocellular/enterobacteriaceae/lipopolysaccharides/Toll-like receptor 4/review分类
医药卫生引用本文复制引用
黄蓉,倪加加,高毅..肠道菌群-脂多糖-Toll样受体4轴与肝细胞癌的关系[J].临床肝胆病杂志,2018,34(6):1325-1328,4.基金项目
国家自然科学基金(81470875) （81470875）
