摘要
Abstract
Objective To explore the efficacy and side effects of amisulpride and risperidone in the treatment of female schizophrenia (SP).Methods A total of 90 female SP patients admitted into our hospital were randomly divided into two groups (n=45,respectively).The observation group was treated with amisulpride,while the control group was treated with risperidone.The effects,changes of body mass index,fasting blood glucose,cholesterol,three acyl glycerol and PANSS score before and after the treatment between the two groups were compared and the adverse drug reactions in the two groups were statistically analyzed.Results The total effective rate of treatment in the observation group (95.56％) was higher than that in the control group (75.56％;P ＜ 0.05).After the treatment,the body mass index,cholesterol and three acyl glycerol increased in the two groups,and those in the observation group were higher than those in the control group (P ＜ 0.05);the PANSS positive symptoms and negative symptoms in the two groups decreased,and those in the observation group were lower than those in the control group (P ＜ 0.05).During the treatment,adverse reactions such as nausea,lethargy and constipation were found in the two groups,but the total incidence in the observation group (8.89％) was lower than that in the control group (26.67％) (P ＜ 0.05).Conclusion The effect of amisulpride in the treatment of female SP is better than that of risperidone,and the incidence of adverse reaction is low.It is worth popularizing in clinical practice.However,the effect of amisulpride on lipid metabolism is greater than that of risperidone.During the treatment,the monitoring and control of blood lipid should be strengthened.关键词
女性/精神分裂症/氨磺必利/利培酮Key words
female/schizophrenia/amisulpride/risperidone分类
医药卫生
