安徽医科大学学报2018，Vol.53Issue(1)：55-58,4.DOI:10.19405/j.cnki.issn1000-1492.2018.01.012
阿帕替尼联合放疗对HeLa细胞周期和凋亡影响的体外研究
Influence of apatinib combined radiotherapy on HeLa cell cycle and apoptosis in vitro
摘要
Abstract
Objective To observe the effect of apatinib (APA) combined with radiotherapy on cell cycle and apoptosis of cervical cancer HeLa cells in vitro. Methods HeLa cells in logarithmic growth phase were divided into control group, drug group, radiotherapy group and joint group. Cell cycle and apoptosis were detected by flow cytometry, and the changes of HeLa cell cycle and apoptosis after radiotherapy were analyzed. Results Retardant of G0/G1 phase for joint group was obviously higher than control and radiotherapy group (P ＜ 0. 05). S phase percentage of joint group was minimum when compared with control group (P ＜0. 05), while there was no significant difference when compared with radiotherapy group. Apoptosis rate of joint group was higher than control group and drug group (P ＜ 0. 05 ). Conclusion APA combined with radiotherapy shows significant G0/G1 phase cell cycle arrest, but no significant induction of apoptosis.关键词
阿帕替尼/放疗/细胞周期/凋亡/宫颈癌/HeLa细胞Key words
apatinib/radiotherapy/cell cycle/apoptosis/cervical cancer/HeLa cell分类
医药卫生引用本文复制引用
刘伟,张建文..阿帕替尼联合放疗对HeLa细胞周期和凋亡影响的体外研究[J].安徽医科大学学报,2018,53(1):55-58,4.基金项目
GSGO-恒瑞肿瘤研究基金(编号:Y-HR2016-046) （编号:Y-HR2016-046）
