安徽医科大学学报2018，Vol.53Issue(1)：66-70,5.DOI:10.19405/j.cnki.issn1000-1492.2018.01.015
USPIO增强MRI在兔动脉粥样硬化斑块模型的观察研究
Study on USPIO enhanced MRI in the detection of atherosclerotic plaques in rabbit models
摘要
Abstract
Objective To evaluate the value of ultrasmall superparamagnetic iron oxide (USPIO) enhanced magnetic resonance imaging(MRI) in the detection of atherosclerotic plaques in rabbits. Methods Thirty male New Zealand white rabbits were randomly divided into two groups: experimental group (n =20) and control group (n =10). The experimental group rabbits were given high-fat diet in order to establish rabbit atherosclerosis models while the control group were given normal diet and without extra intervention. To observe the manifestation of arterial wall under MRI with and without USPIO enhancement to see if there were plaques. Then a pathological section study was made to confirm the existence of arterial plaques. To make a comparison between these two types of examinations. Results Rabbit atherosclerosis models were established successfully. Fourteen rabbits were proved to suffer from atherosclerosis. The central area of the plaques demonstrated a decreased signal with USPIO enhancement. T2WI and the signal-noise ratio value of the vascular wall reach its lowest point after 96 hours, significantly different compared to that before USPIO (P ＜0. 05), while control group negative. The plaques showed a dot-like filling defect on USPIO enhanced PJN 2D-TOF image. Pathological results showed that USPIO particles were mainly deposited under the arterial wall. Conclusion Atherosclerosis models can be established by simple high-fat diet on rabbits. USPIO enhanced MRI can display atherosclerotic plaques in rabbit arterial walls, which could be contribute to the diagnosis and evaluation of atherosclerosis.关键词
动脉粥样硬化/磁共振成像/超微超顺磁性氧化铁/动物模型Key words
atherosclerosis/magnetic resonance imaging/ultrasmall superparamagnetic iron oxide/animal model分类
医药卫生引用本文复制引用
张勇,李小鹏,徐智超,朱华庆,胡孝朋..USPIO增强MRI在兔动脉粥样硬化斑块模型的观察研究[J].安徽医科大学学报,2018,53(1):66-70,5.基金项目
国家自然科学基金(编号:81570419) （编号:81570419）
2015年度安徽医科大学校临床科学研究项目(编号:2015xkj096) （编号:2015xkj096）
