安徽医科大学学报2018，Vol.53Issue(1)：114-118,5.DOI:10.19405/j.cnki.issn1000-1492.2018.01.024
三维斑点追踪技术联合血清肌钙蛋白评价蒽环类药物化疗后乳腺癌患者左心室收缩功能的改变
Evaluation of left ventricular systolic function in patients with breast cancer after anthracycline chemotherapy by three-dimensional tracking technique combined with cardiac troponin
摘要
Abstract
Objective To evaluate the left ventricular global systolic function in patients with breast cancer treated with anthracycline (ATC ) by three-dimensional speckle tracking imaging (3D-STI) technique and serum cardiac troponin T (cTnT), and to investigate whether there were significant differences in cardiac function after chemotherapy in left and right breast cancer patients. Methods A total of 59 breast cancer patients with postoperative anthracycline-based chemotherapy were recruited, which were divided into group A (27 cases with left breast surgery) and group B (32 cases with right breast surgery). Conventional echocardiography and 3D-STI derived parameters were measured before and at 3 and 6 anthracycline-based chemotherapeuticcycles. To compare the differences between the two groups of parameters, and compare whether there was statistically significant changes in cardiac function between the two groups of patients after chemotherapy, if not, then the two groups combined into a whole, the receiver operating characteristic (ROC ) curve analysis of the overall three-dimensional strain parameters of left ventricular systolic function value. The level of serum cTnT at different time points were determined and the correlation between cTnT and global area strain (GAS) was analyzed. Results Global area strain (GAS) and global longitudinal strain (GLS) were significantly lower than those before chemotherapy (P ＜0. 05). The parameters between group A and group B had no signifcant difference, so we combined the two groups into a whole. The area under the ROC curve of the whole GAS was 0. 923, which is the largest, and its optimal cut-off value was-30. 5％, with a sensitivity of 88. 1％ and a specificity of 83. 6％. The serum content of cTnT increased significantly during the whole therapy, the difference was statistically significant (P ＜ 0. 05). Troponin T was negatively correlated with overall GAS(r=-0. 667, P ＜ 0. 05). Conclusion 3D-STI can quantitatively evaluate the left ventricular total systolic function of patients treated with anthracycline, and the serum cTnT increased with GAS decreased, but there is no significant difference in left and right breast cancer.关键词
三维斑点追踪/肌钙蛋白T/心室功能/蒽环类Key words
three-dimensional speckle tracking/troponin T/ventricular function/anthracycline分类
医药卫生引用本文复制引用
吴芳芳,王玲,陈剑琼,刘颂玉,曹雷..三维斑点追踪技术联合血清肌钙蛋白评价蒽环类药物化疗后乳腺癌患者左心室收缩功能的改变[J].安徽医科大学学报,2018,53(1):114-118,5.基金项目
安徽省公益性技术应用研究联动计划项目(编号:15011d04039) （编号:15011d04039）
