安徽医科大学学报2018，Vol.53Issue(1)：132-136,5.DOI:10.19405/j.cnki.issn1000-1492.2018.01.028
结直肠癌细胞增殖核抗原及生长抑制因子4表达的关系及预后因素
Relationship between Ki-67 and ING4 expression and their prognostic significance in colorectal cancer
摘要
Abstract
Objective To investigate the expression of Ki-67 and ING4 and their influence on survival in patients with colorectal cancer. Methods The expressions of Ki-67 and ING4 proteins were detected by immunohistochemistry in colorectal cancer tissues from 71 cases of colorectal cancer and normal colorectal tissues from 30 corresponding para-cancerous normal tissues. The correlations between the expressions of Ki-67, ING4 and clinicopathological parameters and prognostic significance were also analyzed. Results The colorectal cancer tissues's positive expression rates of Ki-67 was 85. 9％, which was significantly higher in innormal tissue group (6. 7％ ) (P ＜ 0. 05 ), The colorectal cancer tissues's positive expression rates of ING4 was 56. 3％, which was significantly lower in innormal tissue group (90％ ) (P ＜ 0. 05). Ki-67 expressions in colorectal cancer tissues were correlated with infiltration depth, lymph node metastasis, number of lymph node metastasis and TNM staging (P ＜ 0. 05 ). ING4 expressions in colorectal cancer tissues were correlated with histological grade, lymph node metastasis, number of lymph node metastasis and TNM staging (P ＜ 0. 05). Ki-67 was negatively correlated with ING4(r =-0.428, P＜0. 05). The 5-year survival rate in the Ki-67 positive group (63. 9％ ) was lower compared with the Ki-67 negative group(85. 5％ ) (P ＜0. 05 ). The 5-year survival rate in the ING4 positive group(97. 4％ ) was higher compared with the ING4 negative group (45. 2％ )(P ＜0. 05). The multivariate analysis showed that TMN stage and ING4 are independent prognostic factors in colorectal cancer. Conclusion Ki-67 and ING4 may be involved in the occurrence and development of colorectal cancer, and ING4 is independent factors affecting the prognosis in patient with colorectal cancer.关键词
结直肠癌/细胞增殖核抗原/生长抑制因子4/预后Key words
colorectal cancer/Ki-67/ING4/prognosis分类
医药卫生引用本文复制引用
孙旭凌,申婧,黄桂林,李豫江,李志刚..结直肠癌细胞增殖核抗原及生长抑制因子4表达的关系及预后因素[J].安徽医科大学学报,2018,53(1):132-136,5.基金项目
新疆生产建设兵团卫生科技计划 （）
