安徽医科大学学报2018，Vol.53Issue(2)：288-292,5.DOI:10.19405/j.cnki.issn1000-1492.2018.02.027
应用3D-STI监测乳癌术后蒽环类药物致左室扭转运动及心肌应变的改变
Application of 3D-STI to monitor left ventricular torsion and changes of myocardial strain in breast cancer patients receiving anthracycline therapy
摘要
Abstract
Objective The changes of left ventricular torsion and strain following the dose accumulation of anthracycline in patients with breast cancer was detected by three-dimensional speckle tracking imaging (3D-STI). Methods A group of 47 breast cancer postoperative patients were recuited and received a six-cycle epirubicin-based chemotherapy. Left ventricular torsion and strain were measured when the epirubicin cumulative dose of 0, 120, 240, 360 mg/m2, They were left ventricular twist (Ptw), left ventricular torsion (Tor), global longitudinal strain, global circumferential strain and overall radial strain, the above parameters were compared and analyzed. The receiver operating characteristics (ROC) curve was constructed to determine optimal sensitivity and specificity for early changes in left ventricular systolic function. 22 female healthy volunteers saved as control subjects. Results Ptw and Tor were significantly lower at the cumulative dose of 120 mg/m2 than 0 mg/m2 (P < 0. 05). The area under the ROC curve of Ptw was 95. 8％, and its optimal cut-off value was 11. 0° with a specificity of 85. 1 ％ and a sensitivity of 93. 6％. The area under the ROC curve of Tor was 89. 6％, and its optimal cut-off value was 1. 30/cm with a specificity of 80. 0％ and a sensitivity of 89. 4％. Conclusion Ptw and Tor has a high specificity and sensitivity in detection of ventricular myocardial dysfunction. 3D-STI is useful in early detect the cardiotoxicity of chemotherapeutic agent in breast cancer patients.关键词
乳腺肿瘤/蒽环类/三维斑点追踪成像技术/扭转运动/心肌应变Key words
breast cancer/anthracycline/three-dimensional speckle tracking imaging/torsion/myocardialstrain分类
医药卫生引用本文复制引用
胡莉莉,郑慧,许芳芳,周旺,陈娜,李朝密,杨筱威..应用3D-STI监测乳癌术后蒽环类药物致左室扭转运动及心肌应变的改变[J].安徽医科大学学报,2018,53(2):288-292,5.基金项目
安徽省公益性研究联动计划项目(编号:160410804027) （编号:160410804027）
